Wnt/β-catenin信号通路对靶基因转录的调控

被引：74

作者：

苏尚

吴畏

机构：

[1] 清华大学生命科学学院

来源：

中国科学:生命科学 | 2014年 / 44卷 / 10期

关键词：

Wnt信号通路; 靶基因; 转录调控;

D O I：

暂无

中图分类号：

Q78 [基因工程（遗传工程）];

学科分类号：

071007 [遗传学];

摘要：

Wnt/β-catenin信号通路又被称为经典Wnt信号通路,在早期胚胎发育、成体组织稳态维持、干细胞干性调控和肿瘤发生等过程中均发挥重要作用.经典Wnt信号通路的核心信号转导因子β-catenin与核内转录因子TCF/LEF家族成员结合后,通过募集或替换一系列协同作用因子,诱导染色质结构变化,调控Wnt信号靶基因的转录.本文将从Wnt信号靶基因转录调控的基本模式、分子机制、表观遗传学调控和意义等方面,总结近年来有关Wnt信号靶基因转录调控的研究成果,方便读者更好地理解Wnt信号通路靶基因的转录调控.

引用

收藏

页码：1029 / 1042

页数：14

相关论文

共 32 条

[1]

非洲爪蟾早期胚胎发育中的Wnt信号 [J].

叶中德 ;

吴畏 .

生命科学, 2007, (04) :359-363

[2]

Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer [J].

Pate, Kira T. ;

Stringari, Chiara ;

Sprowl-Tanio, Stephanie ;

Wang, Kehui ;

TeSlaa, Tara ;

Hoverter, Nate P. ;

McQuade, Miriam M. ;

Garner, Chad ;

Digman, Michelle A. ;

Teitell, Michael A. ;

Edwards, Robert A. ;

Gratton, Enrico ;

Waterman, Marian L. .

EMBO JOURNAL, 2014, 33 (13) :1454-1473

[3]

Distinct DNA Binding Sites Contribute to the TCF Transcriptional Switch in C. elegans and Drosophila [J].

Bhambhani, Chandan ;

Ravindranath, Aditi J. ;

Mentink, Remco A. ;

Chang, Mikyung V. ;

Betist, Marco C. ;

Yang, Yaxuan X. ;

Koushika, Sandhya P. ;

Korswagen, Hendrik C. ;

Cadigan, Ken M. .

PLOS GENETICS, 2014, 10 (02)

[4]

The BRG1 Chromatin Remodeler Regulates Widespread Changes in Gene Expression and Cell Proliferation During B Cell Activation [J].

Holley, Darcy W. ;

Groh, Beezly S. ;

Wozniak, Glenn ;

Donohoe, Dallas R. ;

Sun, Wei ;

Godfrey, Virginia ;

Bultman, Scott J. .

JOURNAL OF CELLULAR PHYSIOLOGY, 2014, 229 (01) :44-52

[5]

Wnt-induced transcriptional activation is exclusively mediated by TCF/LEF [J].

Schuijers, Jurian ;

Mokry, Michal ;

Hatzis, Pantelis ;

Cuppen, Edwin ;

Clevers, Hans .

EMBO JOURNAL, 2014, 33 (02) :146-156

[6]

The Mediator complex and transcription regulation [J].

Poss, Zachary C. ;

Ebmeier, Christopher C. ;

Taatjes, Dylan J. .

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2013, 48 (06) :575-608

[7]

Human Telomerase Reverse Transcriptase (hTERT) Is a Novel Target of the Wnt/β-Catenin Pathway in Human Cancer [J].

Zhang, Yong ;

Toh, LingLing ;

Lau, Peishan ;

Wang, Xueying .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (39) :32494-32511

[8]

Wnt Proteins [J].

Willert, Karl ;

Nusse, Roel .

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2012, 4 (09)

[9]

The Evolution of the Wnt Pathway [J].

Holstein, Thomas W. .

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2012, 4 (07)

[10]

Wnt/β-Catenin Signaling Regulates Telomerase in Stem Cells and Cancer Cells [J].

Hoffmeyer, Katrin ;

Raggioli, Angelo ;

Rudloff, Stefan ;

Anton, Roman ;

Hierholzer, Andreas ;

Del Valle, Ignacio ;

Hein, Kerstin ;

Vogt, Riana ;

Kemler, Rolf .

SCIENCE, 2012, 336 (6088) :1549-1554

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