绝经后骨质疏松与氧化应激相关研究进展

被引：31

作者：

彭涛 ^{[1
]}

李爱国 ^{[2
]}

何培亮 ^{[2
]}

机构：

[1] 贵州医科大学

[2] 广州市红十字会医院暨南大学医学院附属广州红十字会医院

来源：

中外医学研究 | 2020年 / 18卷 / 10期

关键词：

氧化应激; 骨质疏松症; 活性氧;

D O I：

10.14033/j.cnki.cfmr.2020.10.077

中图分类号：

R580 [];

学科分类号：

摘要：

绝经后雌激素水平下降是导致女性骨质疏松的重要因素之一,目前研究发现,绝经患者体内的一共同特征是机体内的氧化应激水平增高。氧化应激是指体内抗氧化与氧化作用失衡,使机体倾向于氧化,导致产生大量氧化产物蓄积,该机制可能打破了成骨细胞和破骨细胞的动态平衡状态,从而造成骨质疏松的发生。目前发现绝经后骨质疏松与氧化应激关系密切,但具体机制尚未完全阐明。本文通过查询国内外文献,对氧化应激与绝经后骨质疏松发病机制的研究进展进行综述,以此对以后抗绝经后骨质疏松药物做出思考。

引用

页码：186 / 188

页数：3

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