APP swe/PS1dE9双转基因阿尔茨海默病模型小鼠生物学特征

被引：31

作者：

高雅 ^{[1
]}

王鲁宁 ^{[2
]}

张红红 ^{[1
]}

机构：

[1] 解放军总医院南楼临床部老年医学研究所

[2] 解放军总医院神经内科

来源：

中华老年心脑血管病杂志 | 2015年 / 17卷 / 01期

关键词：

阿尔茨海默病; 认知障碍; 突变; 小鼠,转基因;

D O I：

暂无

中图分类号：

R749.16 []; R-332 [医用实验动物学];

学科分类号：

100402 [劳动卫生与环境卫生学];

摘要：

<正>阿尔茨海默病(Alzheimer disease,AD)是一种以进行性认知功能障碍和记忆损害为特征的中枢神经系统常见的退行性疾病。AD的主要病理特征为大脑萎缩,脑组织内形成老年斑、神经纤维缠结及神经元丢失。AD的病因和发病机制目前虽未完全明了,但与一些基因的遗传突变密切相关。因此,AD转基因动物模型应运而生,拓展了对该模型鼠的认识,从而对进一步深入探讨AD的发病机制及治疗途径大

引用

页码：106 / 108

页数：3

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