卵巢癌中结缔组织生长因子的表达及其临床病理意义

被引：4

作者：

张宗瑧

邵婷

陈秀玮

王树香

刘天伯

刘运铎

机构：

[1] 哈尔滨医科大学附属第三医院妇一科

来源：

现代生物医学进展 | 2015年 / 15卷 / 12期

关键词：

结缔组织生长因子; 卵巢癌; 转移;

D O I：

10.13241/j.cnki.pmb.2015.12.024

中图分类号：

R737.31 [卵巢肿瘤];

学科分类号：

100214 [肿瘤学];

摘要：

目的:探讨卵巢癌中结缔组织生长因子(CTGF)的表达及其与卵巢癌临床病理特征的关系。方法:采用免疫组化法检测116例卵巢癌和25例正常卵巢组织中CTGF表达,并分析其与卵巢癌临床病理参数的关系。结果:正常卵巢组织及卵巢癌中CTGF的阳性表达率分别96%(24/25)、65%(75/116),卵巢癌中CTGF的阳性表达率显著低于正常卵巢组织(P<0.05)。CTGF的表达降低与卵巢癌患者的淋巴结转移、腹膜内转移及对化疗的敏感性显著相关(P<0.05);进一步的多因素Logistic回归分析显示CTGF的表达与卵巢癌腹膜转移(P=0.006,OR=4.185,95%CI=1.447-11.352)和淋巴结转移(P<0.001,OR=6.336,95%CI=2.563-15.972)均显著相关。结论:卵巢癌中CTGF的表达缺失,是卵巢癌腹膜转移和淋巴结转移的独立影响因素,可能作为预测卵巢癌转移的参考指标。

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收藏

页码：2302 / 2306

页数：5

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