HIF-1α与EMT在肿瘤中的作用及意义研究进展

被引：16

作者：

周明利

卢先州

张树友

机构：

[1] 南华大学附属南华医院普通外科

来源：

中国普通外科杂志 | 2012年 / 21卷 / 09期

关键词：

肿瘤/病因学; 缺氧诱导因子1,α亚基; 上皮间质转化; 综述文献;

D O I：

暂无

中图分类号：

R730.2 [肿瘤病理学、病因学];

学科分类号：

100214 [肿瘤学];

摘要：

缺氧诱导因子1α(HIF-1α)通过调节不同靶基因的转录活性及其自身的表达,参与肿瘤的增殖凋亡与侵袭转移等过程,其过度表达与恶性肿瘤的不良预后有关。上皮/间质转化(EMT)在肿瘤的侵袭和转移过程中起着非常重要的作用,其机制涉及复杂的信号通路、E-钙黏蛋白、Snail转录因子和microRNA等。本文就两者在肿瘤中的作用及意义做一综述。

引用

页码：1132 / 1136

页数：5

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