陷窝蛋白在脑缺血后血脑屏障破坏中的作用

被引：2

作者：

王昭君

王刘敏

林颖

刘亚红

机构：

[1] 南京大学医学院附属金陵医院,南京军区南京总医院神经内科

来源：

国际脑血管病杂志 | 2016年 / 24卷 / 03期

关键词：

卒中; 脑缺血; 血脑屏障; 脑水肿; 细胞质膜微囊蛋白1;

D O I：

暂无

中图分类号：

R743 [脑血管疾病];

学科分类号：

100204 [神经病学];

摘要：

陷窝蛋白是陷窝的主要组成蛋白, 也是实现其生理功能的重要蛋白。陷窝蛋白表达于平滑肌细胞、内皮细胞和脂肪细胞。陷窝既参与了细胞的脂肪摄取、胞吞和胞饮等基本生理过程, 也对细胞的信号转导以及大分子物质的转运和通透起着非常重要的作用。随着对陷窝蛋白的分子构成和生物化学功能研究的深入, 越来越多的研究表明陷窝及其主要成分陷窝蛋白在脑血管病的病理生理学过程起着重要作用。文章就陷窝蛋白在脑缺血后血脑屏障破坏中的作用进行了综述。

引用

共 44 条

[1]

Stepwise Recruitment of Transcellular and Paracellular Pathways Underlies Blood-Brain Barrier Breakdown in Stroke [J].

Knowland, Daniel ;

Arac, Ahmet ;

Sekiguchi, Kohei J. ;

Hsu, Martin ;

Lutz, Sarah E. ;

Perrino, John ;

Steinberg, Gary K. ;

Barres, Ben A. ;

Nimmerjahn, Axel ;

Agalliu, Dritan .

NEURON, 2014, 82 (03) :603-617

[2]

Evidences of endocytosis via caveolae following blood–brain barrier breakdown by Phoneutria nigriventer spider venom.[J].Edilene Siqueira Soares;Monique Culturato Padilha Mendonça;Silvia Pierre Irazusta;Andressa Coope;Leila Miguel Stávale;Maria Alice da Cruz-Höfling.Toxicology Letters.2014, 3

[3]

Caveolin isoform switching as a molecular; structural; and metabolic regulator of microglia.[J].Ingrid R. Niesman;Nathan Zemke;Heidi N. Fridolfsson;Kristofer J. Haushalter;Karen Levy;Anna Grove;Rosalie Schnoor;J. Cameron Finley;Piyush M. Patel;David M. Roth;Brian P. Head;Hemal H. Patel.Molecular and Cellular Neuroscience.2013,

[4]

Blood-Brain Barrier Alterations in the Cerebral Cortex in Experimental Autoimmune Encephalomyelitis [J].

Errede, Mariella ;

Girolamo, Francesco ;

Ferrara, Giovanni ;

Strippoli, Maurizio ;

Morando, Sara ;

Boldrin, Valentina ;

Rizzi, Marco ;

Uccelli, Antonio ;

Perris, Roberto ;

Bendotti, Caterina ;

Salmona, Mario ;

Roncali, Luisa ;

Virgintino, Daniela .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2012, 71 (10) :840-854

[5]

Blood–brain barrier; reperfusion injury; and hemorrhagic transformation in acute ischemic stroke.[J].Rakesh Khatri;Alexander M. McKinney;Barbara Swenson;Vallabh Janardhan.Neurology.2012, 13_S

[6]

Beyond the Time Window of Intravenous Thrombolysis: Standing by or by Stenting? [J].

Liu, Xinfeng .

INTERVENTIONAL NEUROLOGY, 2012, 1 (01) :3-15

[7]

Caveolin-1 regulates nitric oxide-mediated matrix metalloproteinases activity and blood-brain barrier permeability in focal cerebral ischemia and reperfusion injury [J].

Gu, Yong ;

Zheng, Guoqing ;

Xu, Mingjing ;

Li, Yue ;

Chen, Xingmiao ;

Zhu, Wenzong ;

Tong, Yao ;

Chung, Sookja K. ;

Liu, Ke Jian ;

Shen, Jiangang .

JOURNAL OF NEUROCHEMISTRY, 2012, 120 (01) :147-156

[8]

Molecular insights and therapeutic targets for blood–brain barrier disruption in ischemic stroke: Critical role of matrix metalloproteinases and tissue-type plasminogen activator.[J].Rong Jin;Guojun Yang;Guohong Li.Neurobiology of Disease.2010, 3

[9]

Upregulation of caveolin-1 and CD147 expression in nasopharyngeal carcinoma enhanced tumor cell migration and correlated with poor prognosis of the patients [J].

Du, Zi-Ming ;

Hu, Chun-Fang ;

Shao, Qiong ;

Huang, Ma-Yan ;

Kou, Chang-Wei ;

Zhu, Xiao-Feng ;

Zeng, Yi-Xin ;

Shao, Jian-Yong .

INTERNATIONAL JOURNAL OF CANCER, 2009, 125 (08) :1832-1841

[10]

Phosphorylation of Caveolin-1 Regulates Oxidant–Induced Pulmonary Vascular Permeability via Paracellular and Transcellular Pathways.[J].Yu Sun;Guochang Hu;Xiumei Zhang;Richard D. Minshall.Circulation Research.2009, 7

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