P-糖蛋白介导的中枢神经系统药物相互作用

被引：4

作者：

沈沅

李焕德

机构：

[1] 中南大学湘雅二医院临床药学研究室

来源：

中国临床药理学杂志 | 2008年 / 06期

关键词：

P-糖蛋白; 血脑屏障; 中枢神经系统; 药物相互作用;

D O I：

10.13699/j.cnki.1001-6821.2008.06.026

中图分类号：

R969.2 [药物相互作用];

学科分类号：

100706 [药理学];

摘要：

P-糖蛋白(P—gp)属于ATP结合盒转运体超家族成员之一,是目前研究较多的一类转运体,它广泛分布于人体的肠、肝、肾、等部位的管腔上皮细胞和脑毛细血管内皮细胞上。由于临床使用的大多数药物都是P—gp底物和或调节剂,容易引起相应的药物相互作用。本文重点介绍了P—gp与血脑屏障、P—gp对中枢神经系统(CNS)药物作用的研究进展、P—gp介导的相互作用及在中枢神经系统上产生的药物效应或副作用。

引用

页码：533 / 538

页数：6

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