阿片类药物导致便秘的机制及治疗

被引:63
作者
董凤良
杜方民
董小芳
胡建文
机构
[1] 东阳市人民医院消化科
关键词
阿片类药物; 便秘; 阿片受体拮抗剂;
D O I
暂无
中图分类号
R595.3 [药源性疾病];
学科分类号
100201 [内科学];
摘要
阿片类药物是中重度疼痛常用的止痛药物,通过与阿片受体的结合起到止痛的作用,但同时抑制了胃肠道的蠕动和分泌,容易导致便秘、恶心、呕吐等胃肠道不良反应,引起疼痛患者的不适。便秘是阿片类药物最主要的不良反应,而传统的通便药物的治疗效果不佳,目前国外致力于研究治疗阿片类药物导致便秘的新药,这些新药通过阻滞外周阿片受体起到治疗的作用,同时不影响中枢止痛作用。该文就阿片类药物导致便秘的发病机制及目前治疗情况予以综述。
引用
收藏
页码:288 / 291
页数:4
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共 20 条
[1]
Opiate-induced constipation related to activation of small intestine opioid μ2-receptors[J] Wency Chen;Hsien-Hui Chung;Juei-Tang Cheng; World Journal of Gastroenterology 2012,
[2]
Quality of life benefits and cost impact of prolonged release oxycodone/naloxone versus prolonged release oxycodone in patients with moderate-to-severe non-malignant pain and opioid-induced constipation: a UK cost-utility analysis[J] William Dunlop;Reiner Uhl;Iftekhar Khan;Anna Taylor;Garry Barton Journal of Medical Economics 2012,
[3]
Differences in the characteristics of tolerance to μ-opioid receptor agonists in the colon from wild type and β-arrestin2 knockout mice[J] Hercules T. Maguma;William L. Dewey;Hamid I. Akbarali European Journal of Pharmacology 2012,
[4]
Subcutaneous Methylnaltrexone for Treatment of Opioid-Induced Constipation in Patients With Chronic; Nonmalignant Pain: A Randomized Controlled Study[J] Edward Michna;E. Richard Blonsky;Seth Schulman;Evan Tzanis;Amy Manley;Haiying Zhang;Shrividya Iyer;Bruce Randazzo Journal of Pain 2011,
[5]
6β-Naltrexol; a Peripherally Selective Opioid Antagonist that Inhibits Morphine-Induced Slowing of Gastrointestinal Transit: An Exploratory Study[J] Janet Yancey-Wrona;Brian Dallaire;Edward Bilsky;Brad Bath;John Burkart;Lynn Webster;Dan Magiera;Xiaoxia Yang;Mitch Phelps;Wolfgang Sadee Pain Medicine 2011,
[6]
Methylnaltrexone for Opioid-Induced Constipation in Patients With Advanced Illness: A 3-Month Open-Label Treatment Extension Study[J] Arthur G. Lipman;Sloan Karver;Gail Austin Cooney;Nancy Stambler;Robert J. Israel Journal of Pain and Palliative Care Pharmacothera 2011,
[7]
Distinct Relations Among Plasma Concentrations Required for Different Pharmacological Effects in Oxycodone; Morphine; and Fentanyl[J] Atsushi Nakamura;Minoru Hasegawa;Hisanori Ito;Kazuhisa Minami;Katsumi Koike;Naoko Habu-Tomita;Kenkichi Nanba;Kayo Hamaguchi;Eriko Noshi;Hiroshi Hashimoto;Ikuko Nishino;Yoshito Okabayashi;Kiyotaka Koyabu;Tsuyoshi Kihara;Yuka Iwamoto;Yuji Inoue;Minoru Narita;Tsutomu Suzuki;Akira Kato Journal of Pain and Palliative Care Pharmacothera 2011,
[8]
Innovative pain therapy with a fixed combination of prolonged-release oxycodone/naloxone: a large observational study under conditions of daily practice[J] U. Schutter;S. Grunert;C. Meyer;T. Schmidt;T. Nolte Current Medical Research & Opinion 2010,
[9]
Long‐term efficacy and safety of combined prolonged‐release oxycodone and naloxone in the management of non‐cancer chronic pain[J] A.Sandner‐Kiesling;P.Leyendecker;M.Hopp;L.Tarau;J.Lejcko;W.Meissner;P.Sevcik;M.Hakl;R.Hrib;R.Uhl;H.Dürr;K.Reimer International Journal of Clinical Practice 2010,
[10]
Analgesic Efficacy and Safety of Oxycodone in Combination With Naloxone as Prolonged Release Tablets in Patients With Moderate to Severe Chronic Pain[J] Dana Vondrackova;Petra Leyendecker;Winfried Meissner;Michael Hopp;Istvan Szombati;Kai Hermanns;Christian Ruckes;Susanne Weber;Birgit Grothe;Wolfgang Fleischer;Karen Reimer Journal of Pain 2008,