血浆脑源性神经营养因子水平与酒依赖患者认知功能的研究

被引：3

作者：

李强 ^{[1
]}

胡建 ^{[1
]}

谭秀丽 ^{[1
]}

王婷婷 ^{[2
]}

计薇 ^{[3
]}

机构：

[1] 哈尔滨医科大学附属第一医院

[2] 青岛精神卫生中心

[3] 哈尔滨医科大学

来源：

现代生物医学进展 | 2013年 / 13卷 / 10期

关键词：

酒依赖; BDNF; 认知功能;

D O I：

10.13241/j.cnki.pmb.2013.10.040

中图分类号：

R749.62 [];

学科分类号：

摘要：

目的:研究酒依赖患者与正常对照者之间血浆脑源性神经营养因子(BDNF)水平的差异;研究酒依赖患者认知功能与血浆BDNF水平的关系。方法:纳入符合美国精神障碍诊断与统计手册第四版(DSM-Ⅳ)酒依赖诊断标准的酒依赖患者38例和正常对照30例,应用威斯康星卡片分类测验(WCST)和理解记忆测验评定入组对象的认知功能,并应用酶联免疫吸附试验(ELISA法)检测血浆BDNF水平,统计方法采用t检验、秩和检验和直线相关分析。结果:酒依赖患者组血浆BDNF水平低于对照组([3138.79±1195.38)pg/ml与(3656.03±899.56)pg/ml,P<0.05]。酒依赖患者组威斯康星卡片分类测验(WCST)中的正确数和完成分类数的得分低于对照组,有统计学差异(P<0.01);而错误数、持续性错误数、随机错误数均高于对照组,差异有统计学意义(P<0.01)。患者组理解记忆得分低于对照组(P<0.01)。患者组血浆BDNF水平与以下指标呈正相关:威斯康星卡片分类测验中的正确数(r=0.90755,P<0.0001)、完成分类数(r=0.78427,P<0.0001);理解记忆得分(r=0.48340,P=0.0021);患者组血浆BDNF水平与以下指标呈负相关:威斯康星卡片分类测验中的错误数(r=-0.90883,P<0.0001)、持续性错误数(r=-0.82513,P<0.0001)、随机错误数(r=-0.75373,P<0.0001)。结论:(1)本组酒依赖患者血浆BDNF水平低于正常;(2)本研究提示酒依赖患者认知功能损害程度越重其血浆BDNF水平就越低。

引用

页码：1922 / 1926+1936 +1936

页数：6

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