Azone预处理对抗病毒药Ara-ADA穿透无毛小鼠皮肤的持续影响

被引:7
作者
徐惠南
机构
[1] 上海医科大学药学院药剂学教研室上海
关键词
透皮促进利; 1-十二烷基氮杂环庚烷-2酮; 2′,3′-双乙酰阿糖腺苷;
D O I
10.16438/j.0513-4870.1989.04.011
中图分类号
学科分类号
摘要
本文用两个半池组成的扩散池测定4~6周无毛小鼠腹部皮肤用1-十二烷基氮杂环庚烷2酮(Azone)预处理24h后,对抗病毒药2′,3′-双乙酰阿糖腺苷(2′,3′-di-O-acetyl-3-βD arabinofuranosyl adenine简称Ara ADA)透过皮肤促进作用的持续效应。皮肤经Azone处理后,立即或分别测定经历4,5…8d后的穿透系数。结果表明,经Azone处理后的无毛小鼠皮肤可使Ara ADA的穿透系数提高44倍,皮肤经Azone处理一次后,药物透过皮肤的促进作用至少可持续8d,药物通过皮肤的扩散时滞明显缩短。
引用
收藏
页码:290 / 294
页数:5
相关论文
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