Eph受体家族及其配体的信号转导途径及功能

被引:7
作者
张晓光
药立波
苏成芝
机构
[1] 第四军医大学生物化学与分子生物学教研室!西安
关键词
Eph受体; ephrin配体; 酪氨酸蛋白激酶受体;
D O I
暂无
中图分类号
R392.12 [免疫细胞生物学];
学科分类号
100102 ;
摘要
Eph受体是已知最大的酪氨酸蛋白激酶受体家族 ,Eph受体和其膜附着型配体 (ephrin)在发育过程中呈现不同的表达模式 ,近来研究证明 ,Eph受体和其配体在包括神经网络形成 ,神经管和轴旁中胚层的成型(patterning) ,细胞迁移导向和轴突路径导引 ,血管形成等许多的发育过程中起重要作用 .Eph受体及其配体也与肿瘤发生有关 ,因此深入分析这些分子尤其在肿瘤细胞生长中的功能而应用于治疗具有重要的临床意义
引用
收藏
页码:498 / 501
页数:4
相关论文
共 19 条
[1]  
Eph receptors and ephrins restrict cell intermingling and communication. Mellitzer G,Xu Q,Wilkinson D G,et al. Nature . 1999
[2]  
An early developmental role for eph-ephrin interaction duing vertebrate gasteulation. Oates A C,Lackmann M,Power M A,et al. Mechanisms of Development . 1999
[3]  
Fibroblast growth factor receptor-mediated rescue of x-Ephrin B1-induced cell dissociation in xenopus embryos. Chong L D,Park E K,Latimer E. Molecular and Cellular Biology . 2000
[4]  
Neuron[P]. KUTKOVETSKYI VALENTYN YAKOVYCH;TURTI MARYNA VALENTYNIVNA.UA106289U,2016-04-25
[5]  
Overexpression of ERK, an EPH family receptor protein tyrosine kinase, in various human tumors. Kiyokawa E,Takai S,Tanaka M. Cancer Research . 1994
[6]  
Roles of ephrinB ligands and EphB receptors in cardiovascular development:demarcation of arterial/venous domains, vascular morphogenesis,and sprouting angiogenesis. Adams R H,Wilkinson G A,Weiss C,et al. Genes and Development . 1999
[7]  
Solution structure of the receptor tyrosine kinase EphB2 EphB2 SAM domain and identi fication of two distinct homotypic interaction sites. Smalla M,Schmieder P,Kelly M,et al. Protein Science . 1999
[8]  
The receptor tyrosine kinase EphB4 and ephrin-B ligands restrict angiogenic growth of embryonic veins in Xenopus laevis. Helbling P M,Saulnier D M,Brandli A W. Development . 2000
[9]  
Characterization of a novel Srclike adapter protein that associates with the Eck receptor tyrosine kinase. Pandey A,Duan H,Dixit V M. Journal of Biological Chemistry . 1995
[10]  
Multiple in vivo tyrosine phosphorylation sites in EphB receptors. Kalo M S,Pasquale E B. Biochemistry . 1999