缺血性脑卒中患者血浆NO浓度变化的研究

被引：8

作者：

王立

徐俊

陈月琴

机构：

[1] 南京医科大学附属脑科医院

[2] 中山医科大学博士生

来源：

临床神经病学杂志 | 2001年 / 05期

关键词：

缺血性脑卒中; NO; 血浆;

D O I：

暂无

中图分类号：

R743 [脑血管疾病];

学科分类号：

1002 ;

摘要：

目的　研究不同类型的缺血性脑卒中患者的血浆一氧化氮 (NO)浓度变化及其临床意义。方法采用硝酸还原酶法测定 2 30例脑梗死患者、10 3例腔隙性脑梗死患者以及 16 9名正常对照者的血浆 NO浓度。结果　脑梗死组血浆 NO浓度与另两组相比显著增高 (均 P<0 .0 0 1) ,而腔隙性脑梗死患者的血浆 NO浓度低于对照组 (P<0 .0 5 )。结论　脑梗死患者急性期血浆 NO浓度可作为缺血损害的一个参考指标 ;而腔隙性脑梗死组 NO浓度下降反映患者的高血压等基础病变的存在

引用

页码：269 / 271

页数：3

共 6 条

[1]

Reduced endothelial nitric oxide synthase expression and production in human atherosclerosis. Oemar BS,Tschdi MR,Godoy N,et al. Circulation . 1998

[2]

Nitric oxide synthase inhibition in human’ s reduce cerebral blood flow but not the hyperemic response to hypercapnia. White RP,Deane C,Vallance P,et al. Stroke . 1998

[3]

Cationic polymer and lipids enhance adenovirus-mediated gene transfer to rabbit carotid artery. Toyoda K,Ooboshi H,Chu Y,et al. Stroke . 1998

[4]

Delayed reduction of ischemic brain injury and neurological defecits in mice lacking the inducible nitric oxide synthase gene. Iadecola C,Zhang F,Casey R,et al. The Journal of Neuroscience . 1997

[5]

Nitric oxide synthase inhibition and cerebravasular regulation. Iadecola C,Pelligrino DA,Moskowitz MA,et al. Journal of Cerebral Blood Flow and Metabolism . 1992

[6]

Potentiation of nitricc oxide formation following bilateral carotid occlusion and focal cerebral ischemia in the rat : in vivo detection of the nitric oxide radical by electron paramagnetic resonance spin trapping. Tominaga T,Sato S,Ohnishi T,et al. Brain Research . 1993

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