肝纤维化治疗研究进展

被引:5
作者
谢渭芬
林勇
机构
[1] 第二军医大学长征医院消化内科
关键词
肝纤维化; 细胞外基质; 治疗;
D O I
10.16781/j.0258-879x.2002.01.041
中图分类号
R575.05 [];
学科分类号
摘要
肝纤维化的特征性变化是肝内细胞外基质的过多沉积。通过控制肝纤维化发生的各个环节 ,包括减少炎症或抑制宿主免疫反应 ,抑制肝星形细胞的激活和细胞外基质的合成 ,以及促进基质降解和肝细胞再生等已成为治疗该病的重要途径。近年来 ,随着分子生物学研究的不断深入 ,肝纤维化的基因治疗也取得了较大进展。
引用
收藏
页码:93 / 95
页数:3
相关论文
共 20 条
  • [1] Remission of liver fibrosis by interferon alpha 2b. Moreno MG,Muriel P. Biochemical Pharmacology . 1995
  • [2] I n vivo inhibition of rat stellate cell activation by soluble transforming growth factor type Ⅱ receptor: A potential new therapy for hepatic fibrosis. George J,Roulot D,Koteliansky VE,et al. Proceedings of the National Academy of Sciences of the United States of America . 1999
  • [3] An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection. Wynn TA,Cheever AW,Jankovic D,et al. Nature . 1995
  • [4] An IL-13 inhibitor blocks the development of hepatic fibrosis during a Thelper type 2-dominated inflammatory response. Chiaramonte MG,Donaldson DD,Cheever AW,et al. The Journal of Clinical Investigation . 1999
  • [5] Reversal of advanced liver fibrosis in rabbits with Schistosomiasis japonica. Dunn MA,Cheever AW,Paglia LM,et al. American Journal of Tropical Medicine and Hygiene . 1994
  • [6] OK-432 treatment increases matrix metalloproteinase-9 production and improves dimethylnitrosamine-induced liver cirrhosis in rats. Ueno T,Sujaku k,Tamaki S,et al. International Journal of Molecular Medicine . 1999
  • [7] Nutural inhibitor of transforming growth factor-beta protects against scarring in experimental kidney disease. Border WA,Noble NA,Yamamoto T,et al. Nature . 1992
  • [8] Enhanced interstitial collagenase ( matrix metalloproteinase-13 ) production of kupffer cell by gadolinium chloride prevents pig serum-induced rat liver fibrosis. Hironaka K,Sakaida I,Matsumura Y,et al. Biochemical and Biophysical Research Communications . 2000
  • [9] Effects of S-adenosylmethionine on lipid peroxidation and liver fibrogenesis in carbon tetrachloride-induced cirrhosis. Gasso M,Rubio M,Varela G,et al. Journal of Hepatology . 1996
  • [10] Prolyl 4-hydroxylase inhibitor (HOE 077) inhibits pig serum-induced rat liver fibrosis by preventing stellate cell activation. Matsumura Y,Sakaida I,Uchida K,et al. Journal of Hepatology . 1997