氟特嗪胶囊治疗晚期胃癌的Ⅱ期临床研究

被引：18

作者：

杨俊兰

焦顺昌

戴广海

李方

赵宏

李瑛

机构：

[1] 中国人民解放军总医院肿瘤内科

[2] 中国人民解放军总医院肿瘤内科北京市

来源：

中国肿瘤临床 | 2008年 / 01期

关键词：

氟特嗪胶囊; 顺铂; 晚期胃癌;

D O I：

暂无

中图分类号：

R735.2 [胃肿瘤];

学科分类号：

100112 [医学生物化学与分子生物学];

摘要：

目的:以替加氟加顺铂为对照组,观察氟特嗪胶囊(FTQ)加顺铂,治疗晚期胃癌的安全性和有效性。方法:采用多中心、随机、单盲对照方法,共有226例晚期胃癌患者进入随机临床研究,其中191例患者可评价疗效。结果:试验组的有效率(31.31%对6.52%)、临床好转率(53.54%对23.91%)及临床受益率(90.91%对76.09%)均明显高于对照组。氟特嗪胶囊组的血液学毒性与替加氟组基本相同,但其消化道反应明显低于替加氟组。结论:氟特嗪胶囊加顺铂的联合方案是治疗晚期胃癌有效且安全的方案。

引用

页码：8 / 11

页数：4

共 5 条

[1]

Doxifluridine combined with weekly paclitaxel for second-line treatment in patients with gastric cancer resistant to TS-1[J] Wataru Arai;Yoshinori Hosoya;Masanobu Hyodo;Hidenori Haruta;Kentaro Kurashina;Shin Saito;Yuuki Hirashima;Taku Yokoyama;Toru Zuiki;Kazuya Sakuma;Yoshikazu Yasuda;Hideo Nagai International Journal of Clinical Oncology 2007,

[2]

A phase I/II study of S-1 plus cisplatin in patients with advanced gastric cancer: 2-week S-1 administration regimen[J] Yasuhiro Sato;Hitoshi Kondo;Kana Honda;Daisuke Takahari;Tetsuya Sumiyoshi;Yasushi Tsuji;Naohito Yoshizaki;Yoshiro Niitsu International Journal of Clinical Oncology 2005,

[3]

Combination chemotherapy of S-1 and low-dose cisplatin for advanced gastric cancer[J] Shunichi Tsujitani;Kenji Fukuda;Nobuaki Kaibara Gastric Cancer 2003,

[4]

Development of a novel form of an oral 5-fluorouracil derivative (S-1) directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators[J] Tetsuhiko Shirasaka;Yuji Shimamato;Hideyuki Ohshimo;Masahiro Yamaguchi;Toshiyuki Kato;Kazuhiko Yonekura;Masakazu Fukushima Anti-Cancer Drugs 1996,

[5]

An advancedpulmonary adenocarcinoma case in which TS-1 proved ef-fective Hayashi H;Mastushima Y;Kato H;et al; Gan To Kagaku Ryoho 2006,

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