晚期糖基化终产物在动脉粥样硬化中的作用

被引：4

作者：

贺艳红

袁晓晨

张振刚

机构：

[1] 扬州大学第二附属医院心内科

来源：

中华临床医师杂志(电子版) | 2014年 / 8卷 / 05期

关键词：

糖基化终产物,高级; 动脉粥样硬化; 糖尿病; 晚期糖基化终产物受体;

D O I：

暂无

中图分类号：

R543 [血管疾病];

学科分类号：

1002 ; 100201 ;

摘要：

2型糖尿病患者动脉粥样硬化的发病率明显增高。糖尿病通过增加常规的危险因素(如血脂异常、高血压)或糖尿病特有的危险因子(如晚期糖基化终产物AGEs),促进动脉粥样硬化的发展。AGEs作为蛋白质或脂质与还原糖糖基化的终产物,在血管细胞中通过与RAGE结合促进炎症因子的表达,参与动脉粥样硬化的发展。近年来,关于AGEs及其受体(RAGE)对糖尿病动脉粥样硬化影响的研究较为深入。本文旨在对近年来有关AGEs/RAGE在糖尿病加速的动脉粥样硬化中作用的研究进展作一综述。

引用

页码：914 / 917

页数：4

共 15 条

[1]

Effect of dietary nitrate on blood pressure, endothelial function, and insulin sensitivity in type 2 diabetes[J] . Mark Gilchrist,Paul G. Winyard,Kunihiko Aizawa,Christine Anning,Angela Shore,Nigel Benjamin.Free Radical Biology and Medicine . 2013

[2] Involvement of advanced glycation end product-induced asymmetric dimethylarginine generation in endothelial dysfunction [J].

Ando, Ryotaro ;

Ueda, Seiji ;

Yamagishi, Sho-ichi ;

Miyazaki, Hiroshi ;

Kaida, Yusuke ;

Kaifu, Kumiko ;

Yokoro, Miyuki ;

Nakayama, Yosuke ;

Obara, Nana ;

Fukami, Kei ;

Takeuchi, Masayoshi ;

Okuda, Seiya .

DIABETES & VASCULAR DISEASE RESEARCH, 2013, 10 (05) :436-441

[3] Advanced Glycated End-Products Affect HIF-Transcriptional Activity in Renal Cells [J].

Bondeva, Tzvetanka ;

Heinzig, Juliane ;

Ruhe, Carola ;

Wolf, Gunter .

MOLECULAR ENDOCRINOLOGY, 2013, 27 (11) :1918-1933

[4] Functional Role of Soluble Receptor for Advanced Glycation End Products in Stroke [J].

Tang, Sung-Chun ;

Wang, Yu-Chi ;

Li, Yu-I ;

Lin, Hsiao-Ching ;

Manzanero, Silvia ;

Hsieh, Yu-Hsuan ;

Phipps, Simon ;

Hu, Chaur-Jong ;

Chiou, Hung-Yi ;

Huang, Yi-Shuian ;

Yang, Wei-Shiung ;

Mattson, Mark P. ;

Arumugam, Thiruma V. ;

Jeng, Jiann-Shing .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2013, 33 (03) :585-594

[5] Puerarin inhibits the retinal pericyte apoptosis induced by advanced glycation end products in vitro and in vivo by inhibiting NADPH oxidase-related oxidative stress [J].

Kim, Junghyun ;

Kim, Ki Mo ;

Kim, Chan-Sik ;

Sohn, Eunjin ;

Lee, Yun Mi ;

Jo, Kyuhyung ;

Kim, Jin Sook .

FREE RADICAL BIOLOGY AND MEDICINE, 2012, 53 (02) :357-365

[6] ERK and Akt signaling pathways are involved in advanced glycation end product-induced autophagy in rat vascular smooth muscle cells [J].

Hu, Pengfei ;

Lai, Dongwu ;

Lu, Peilin ;

Gao, Jing ;

He, Hong .

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2012, 29 (04) :613-618

[7] Interleukin-17A Deficiency Accelerates Unstable Atherosclerotic Plaque Formation in Apolipoprotein E-Deficient Mice [J].

Danzaki, Keiko ;

Matsui, Yutaka ;

Ikesue, Masahiro ;

Ohta, Daichi ;

Ito, Koyu ;

Kanayama, Masashi ;

Kurotaki, Daisuke ;

Morimoto, Junko ;

Iwakura, Yoichiro ;

Yagita, Hideo ;

Tsutsui, Hiroyuki ;

Uede, Toshimitsu .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2012, 32 (02) :273-U255

[8]

Plasma levels of soluble receptor for advanced glycation end products (sRAGE) and proinflammatory ligand for RAGE (EN-RAGE) are associated with carotid atherosclerosis in patients with peritoneal dialysis[J] . Jwa-Kyung Kim,Sungha Park,Mi Jung Lee,Young Rim Song,Seung Hyeok Han,Sung Gyun Kim,Shin-Wook Kang,Kyu Hun Choi,Hyung Jik Kim,Tae-Hyun Yoo.Atherosclerosis . 2011 (1)

[9] Association between serum levels of soluble receptor for advanced glycation end products and circulating advanced glycation end products in type 2 diabetes [J].

Tan, K. C. B. ;

Shiu, S. W. M. ;

Chow, W. S. ;

Leng, L. ;

Bucala, R. ;

Betteridge, D. J. .

DIABETOLOGIA, 2006, 49 (11) :2756-2762

[10]

Advanced Glycation End Products: Sparking the Development of Diabetic Vascular Injury[J] . Alison Goldin,Joshua A. Beckman,Ann Marie Schmidt,Mark A. Creager.Circulation . 2006 (6)

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