基于TGF-β1/Smads信号通路中医药防治哮喘气道重塑研究进展

被引：20

作者：

赵欣欣 ^{[1
]}

万力生 ^{[2
]}

李佳曦 ^{[2
]}

陈争光 ^{[2
]}

机构：

[1] 遵义医学院珠海校区

[2] 深圳市儿童医院

来源：

辽宁中医药大学学报 | 2016年 / 18卷 / 01期

关键词：

中医药; TGF-β1/Smads信号通路; 哮喘; 气道重塑;

D O I：

10.13194/j.issn.1673-842x.2016.01.053

中图分类号：

R259 [现代医学内科疾病];

学科分类号：

100201 [内科学];

摘要：

小儿支气管哮喘是儿科临床常见性、难治性疾病,中医药在治疗小儿支气管哮喘方面具有显著优势,但其作用机制目前尚未完全阐明。国内外研究发现TGF-β1/Smads信号通路与哮喘气道重塑具有密切关系。该文对TGF-β1/Smads信号通路的信号转导途径和生物学功能进行了详细的阐述,综述了TGF-β1/Smads信号通路与小儿支气管哮喘气道重塑之间的相关性以及中医药通过对TGF-β1/Smads信号通路的调控作用治疗小儿支气管哮喘的机制。同时,对TGF-β1/Smads信号通路在中医药中的研究进行了展望。

引用

页码：160 / 163

页数：4

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