人大肠癌nm23基因与癌组织浸润转移关系的研究

被引：5

作者：

陈晓黎

黄莺

王康敏

机构：

[1] 西安第二临床医学院病理学教研室!西安

来源：

西安医科大学学报 | 1997年 / 02期

关键词：

大肠肿瘤; 基因表达; 转移;

D O I：

暂无

中图分类号：

R735.35 [];

学科分类号：

100214 ;

摘要：

应用免疫组化ABC法，研究43例大肠癌组织中nm23基因产物／NDPK的表达与癌组织浸润转移的关系。结果显示，NDPK在大肠癌原发灶中有较高的表达，阳性率为74．4％，无区域淋巴结转移者阳性率（84．0％）比有区域淋巴结转移者阳性率（61．0％）高，两者比较具有显著性差异（P＜0．05）。原发灶中nm23／NDPK的阳性表达与癌组织浸润深度密切相关，说明nm23／NDPK对肿瘤的浸润转移有重要的抑制作用。还提示，nm23／NDPK的表达不仅与肿瘤的浸润转移有关，还与大肠癌的组织学类型有关。因此，检测大肠癌组织中nm23／NDPK的表达情况，可预测肿瘤的转移和复发。

引用

页码：168 / 170

页数：3

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