缺血性卒中患者血管周围间隙扩大与卒中后抑郁的相关性

被引：10

作者：

曹志永 ^{[1
,2
]}

刘至阳 ^{[2
]}

汪莉 ^{[2
]}

杨春 ^{[2
]}

宋月楠 ^{[2
]}

孙剑 ^{[2
]}

机构：

[1] 镇江, 江苏大学

[2] 常州,

来源：

国际脑血管病杂志 | 2015年 / 23卷 / 03期

关键词：

卒中; 脑缺血; 抑郁障碍; 小动脉; 细胞外隙; 扩张, 病理性; 磁共振成像; 危险因素;

D O I：

暂无

中图分类号：

R743.3 [急性脑血管疾病（中风）]; R749 [精神病学];

学科分类号：

100205 ;

摘要：

目的探讨急性缺血性卒中患者血管周围间隙扩大(enlarged perivascular space, EPVS)与卒中后抑郁(post-stroke depression, PSD)的相关性。方法前瞻性连续入组2010年3月至2014年3月期间住院治疗的急性脑梗死患者, 入院后完成头颅MRI检查并进行EPVS分级, 在发病3个月时根据汉密尔顿抑郁量表(Hamilton Depression Scale, HAMD)和《中国精神障碍分类与诊断标准(第3版)》进行PSD评定, 分析EPVS与PSD之间的联系。结果共入组249例患者, 其中62例(4.9%)在3个月时发生PSD。PSD组基线美国国立卫生研究院卒中量表评分[中位数(四分位数间距);4(3～6)分对3(2～5)分;Z=–2.950, P=0.003]以及半卵圆中心(χ2=14.370, P=0.001)和侧脑室旁(χ2=11.590, P=0.003)EPVS分级患者构成比与非PSD组差异存在统计学意义。多变量logistic回归分析显示, 半卵圆中心EPVS2级[优势比(odd ratio,OR)3.89, 95%可信区间(confidence interval,CI)1.59～9.56]和3级(OR 3.28, 95%CI 1.04～10.33)与PSD显著相关;侧脑室旁EPVS 2级(OR 0.72, 95%CI 0.27～1.91)和3级(OR 2.24, 95%CI 0.68～7.37)与PSD无关。结论半卵圆中心EPVS与PSD独立相关, 而侧脑室旁EPVS则不然。

引用

页码：180 / 183

页数：4

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