肿瘤细胞发生细胞上皮-间质转变机制的研究

被引：25

作者：

赵俊卿 ^{[1
]}

李云峰 ^{[2
]}

杨之斌 ^{[2
]}

机构：

[1] 昆明医学院临床肿瘤学院

[2] 不详

来源：

肿瘤 | 2010年 / 30卷 / 10期

关键词：

肿瘤; 肿瘤转移; 上皮细胞; 信号转导; EMT;

D O I：

暂无

中图分类号：

R730.2 [肿瘤病理学、病因学];

学科分类号：

摘要：

细胞上皮-间质转变(epithelial-mesenchymal transition,EMT),与肿瘤的局部浸润以及远处转移有着非常密切的关系。肿瘤细胞EMT的发生包括诸多因素,主要有转录因子表达上调以及信号通路[如磷脂酰肌醇3-激酶(phosphatidyl inositol-3kinase,PI3K)/蛋白激酶B(protein kinase B,PKB,又称AKT)通路和Ras/丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)通路等]开启等,从而促使细胞间黏附力下降,失去了上皮细胞的顶底极性,并伴随细胞形态的改变。其中E-钙黏着糖蛋白(E-cadherins,E-cad)的表达下调或沉默是EMT发生的重要标志。本文就肿瘤细胞EMT发生机制的最新研究进展作一综述。

引用

页码：890 / 893

页数：4

共 7 条

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