紫杉醇的最新研究进展

被引：21

作者：

袁金辉

郭立霞

王兴旺

谢弘

机构：

[1] 中国科学院上海生物化学与细胞生物学研究所!上海

来源：

中国药理学通报 | 2001年 / 02期

关键词：

紫杉醇; 细胞毒作用; 免疫活性; 耐药;

D O I：

暂无

中图分类号：

R965 [实验药理学];

学科分类号：

摘要：

紫杉醇通过激活肿瘤细胞的Ｆａｓ／ＦａｓＬ通路及半胱氨酸－天冬氨酸蛋白酶诱导凋亡，ｂｃｌ－２对紫杉醇诱导的凋亡也有重要的调节作用。紫杉醇还具有脂多糖样活性，可诱导巨噬细胞释放肿瘤坏死因子α、白介素和一氧化氮等。肿瘤细胞对紫杉醇的耐药研究也有不少新进展。

引用

页码：135 / 139

页数：5

共 11 条

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