抗生素对肠道定植抗力的影响研究进展

被引：25

作者：

方鼎丽

方芳

郭沁园

薛云新

王岱

机构：

[1] 分子疫苗学和分子诊断学国家重点实验室厦门大学公共卫生学院

来源：

中国抗生素杂志 | 2021年 / 46卷 / 02期

关键词：

抗生素; 肠道菌群; 定植抗力;

D O I：

10.13461/j.cnki.cja.006980

中图分类号：

R978.1 [抗生素];

学科分类号：

100103 [病原生物学];

摘要：

哺乳动物的胃肠道寄居着复杂的微生物种群,这些微生物种群被称为肠道微生物群,其与宿主的健康和疾病状态息息相关。肠道菌群可以防止外源病原体在胃肠道中定植,这种现象被称为"定植抗力"。对肠道微生态的干扰,譬如抗生素的使用,可能会改变微生物的组成,影响宿主免疫功能,并导致定植抗性的丧失,从而使宿主易于被病原体定植。本文对肠道定植抗力的形成机制以及抗生素对定植抗力影响的研究进展进行综述,旨在为人们合理使用抗生素、研发抗生素替代疗法提供理论参考。

引用

收藏

页码：113 / 120

页数：8

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