重组水蛭素对兔髂总动脉球囊损伤后内膜增殖影响的实验研究

被引：12

作者：

田建伟

陈宏

刘朝中

江一清

朴龙松

机构：

[1] 第四军医大学与空军总医院!联合培养硕士研究生

[2] 解放军空军医院

[3] 空军总医院心血管内科!北京

来源：

心脏杂志 | 2000年 / 03期

关键词：

血管成形术; 重组水蛭素; 再狭窄; 内膜增殖;

D O I：

10.13191/j.chj.2000.03.12.tianjw.004

中图分类号：

R543.31 [];

学科分类号：

摘要：

目的 :探讨重组水蛭素对兔髂总动脉球囊损伤后内膜增殖的影响。方法 :2 4只纯种日本大耳白兔随机分成肝素对照组 (n=12 )和重组水蛭素组 (n=12 ) ,采用兔髂总动脉球囊扩张损伤后内膜增殖动物模型 ,术后 2周和 4周复查血管造影 ,术后 4周处死动物取髂总动脉标本。结果 :用药组术后 2周和 4周平均髂总动脉直径均较对照组明显增加 (P<0 .0 1) ,4周后新生内膜面积显著减少 (P<0 .0 1) ,管腔面积明显扩大 (P<0 .0 1)。结论 :重组水蛭素可显著减轻兔髂总动脉球囊扩张损伤后新生内膜增殖和管腔的狭窄

引用

页码：174 / 176

页数：3

共 9 条

[1] Neointima formation after acute vascular injury:Role of counteradhensive extracellular metrix protins. Majesky MW. Texas Heart Institute Journal . 1994
[2] Incidence of restenosis after successful coronary angioplasty: a time related phenomenon. Serruys PW,Luijten HE,Beatt KJ,et al. Circulation . 1988
[3] Hirudin interruption of heparin-resistant arterial thrombus formation in baboons. Kelly AB,Marzec VM,Krupski W,et al. Blood . 1991
[4] Effect of thrombin on release of plasminogen activator inhibitor-1 from cutured primate arterial smooth muscle cells. Cockell KA,Ren S,Sun J,et al. Thrombosis Research . 1995
[5] Platelet accumulation in experimental angioplasty: Time course and relation to vascular injury. Wilentz JR,Sanborn TA,Haudenschild CC,et al. Circulation . 1987
[6] Thrombininduced mitogenesis in cultured aortic smooth muscle cells requires prolonged thrombin exposure. Bachhuber BG,Sarembock IJ,Gimple LW,et al. American Journal of Physiology . 1995
[7] Effects of thrombin inhibition on the development of acute platelet -thrombus deposition during angioplasty on pigs: Heparin versus recombinant hirudin, a specific thrombin inhibitor. Heras M,Chesebro JH,Penny WJ,et al. Circulation . 1989
[8] Folow up clinical results in patient undergoing percutaneous transluminal coronary angioplasty. Mabin TA,Holmes DR,Smith HC,et al. Circulation . 1985
[9] Restenosis after percutaneous transluminal coronary angioplasty ( PTCA ): a report from the PTCA Registry of the national heart , lung and blood institute. Holmes DR,Vlietetra RE,Smith HC,et al. The American Journal of Cardiology . 1984

← 1 →