扩张型心肌病伴心力衰竭患者肝细胞生长因子与心功能的相关性研究

被引：4

作者：

罗显元

陈晓华

李祁

何熬林

机构：

[1] 江苏大学附属昆山市第一人民医院友谊院区内科

来源：

中国循证心血管医学杂志 | 2013年 / 5卷 / 03期

关键词：

扩张型心肌病; 肝细胞生长因子; 心功能不全;

D O I：

暂无

中图分类号：

R542.2 [心肌疾病];

学科分类号：

1002 ; 100201 ;

摘要：

目的探讨扩张型心肌病伴心力衰竭患者血清肝细胞生长因子(HGF)浓度与心功能分级的关系。方法纳入2011年至2013年扩张型心肌病伴心力衰竭患者63例作实验组,进一步按照NYHA心功能分级分为Ⅰ级组(n=15)、Ⅱ级组(n=16)、Ⅲ级组(n=15)和Ⅳ级组(n=17),纳入同期健康志愿者32例作对照组。采用酶联免疫吸附法(ELISA)测定HGF浓度,电化学发光法测定血清N端脑钠肽前体(NT-proBNP)浓度,行心脏超声检查左心室舒张末期内径(LVEDD)和左心室射血分数(LVEF),并采用线性回归分析血清HGF浓度和上述指标的相关性。结果实验组各亚组的HGF浓度、NT-proBNP浓度、LVEDD值均高于对照组,差异有统计学意义(P<0.05),且心力衰竭程度越重,上述指标值越高,各组两两之间均存在统计学差异(P<0.05);实验组各亚组LVEF值均低于对照组,差异有统计学意义(P<0.05);血清HGF浓度与NT-proBNP浓度和LVEDD均呈正相关,相关系数分别为0.79和0.73,与LVEF值负相关,相关系数为-0.69(P均<0.05)。结论扩张型心肌病伴心功能不全患者血清HGF浓度和心功能不全的严重程度相关,对判断心功能不全严重程度有帮助。

引用

页码：288 / 289+292 +292

页数：3

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