苯乙酸钠降低肿瘤细胞产生免疫抑制因子

被引：2

作者：

吉家祥

马宝骊

机构：

[1] 上海第二医科大学

来源：

中国肿瘤生物治疗杂志 | 1997年 / 01期

关键词：

苯乙酸钠; 肿瘤; 免疫抑制因子;

D O I：

暂无

中图分类号：

R730.3 [肿瘤免疫学与血清学];

学科分类号：

摘要：

以PHA激活的外周血淋巴细胞增殖以及LAK细胞杀伤K562细胞两项指标来检测肿瘤细胞系MCF7、MDA-453、MKN-45、Hela以及3AO细胞培养上清液中免疫抑制因子的活性.实验结果发现:所有的肿瘤细胞培养上清液都能在不同程度上抑制PHA激活的淋巴细胞增殖.除了MDA-453细胞外,其它肿瘤细胞培养上清液亦能抑制LAK细胞的杀伤活性.因此,这些肿瘤细胞培养上清液中确实存在着免疫抑制因子.以肿瘤细胞分化诱导剂苯乙酸钠处理肿瘤细胞,其培养上清液对PHA激活的淋巴细胞增殖以及IAK细胞杀伤活性的抑制作用显著降低.因此,苯乙酸钠能够降低肿瘤细胞产生的免疫抑制因子.

引用

页码：54 / 57

页数：4

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