IL-35在炎症性肠病中的表达及临床价值

被引：15

作者：

唐文静

王婷婷

汪良芝

机构：

[1] 苏州大学附属第三医院消化内科

来源：

中国医药生物技术 | 2016年 / 11卷 / 02期

关键词：

结肠炎,溃疡状; Corhn病; IL-35; 疾病活动度;

D O I：

暂无

中图分类号：

R574.62 [结肠疾病];

学科分类号：

100201 [内科学];

摘要：

目的探讨血清IL-35在炎症性肠病(IBD)患者血清中的表达及意义。方法采用双抗夹心酶联免疫吸附法(ELISA)检测101例IBD患者及69例健康对照组的血清IL-35和TNF-α的浓度,采用相关分析法分析实验组血清IL-35水平与炎症指标的相关性。结果溃疡性结肠炎(UC)、克罗恩病(CD)和健康对照组的血清IL-35浓度分别为(41.34±16.06)、(48.85±19.14)和(78.17±17.96)pg/ml,差异有统计学意义(P<0.05);UC和CD患者血清IL-35浓度均随着疾病活动度的增加而降低,各等级间差异有统计学意义(P<0.05)。IBD组血清IL-35浓度与血清TNF-α浓度呈负相关(γ=–0.321,P=0.001)。结论 IBD患者血清IL-35水平明显低于正常人,并且与疾病活动度、TNF-α相关。

引用

页码：142 / 144

页数：3

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