晚期胃癌靶向治疗进展

被引:7
作者
黄鼎智
巴一
机构
[1] 天津医科大学肿瘤医院消化肿瘤内科,国家肿瘤临床医学研究中心,天津市肿瘤防治重点实验室
关键词
胃癌; 异质性; 靶向治疗; 基因; 化疗;
D O I
暂无
中图分类号
R735.2 [胃肿瘤];
学科分类号
100112 [医学生物化学与分子生物学];
摘要
胃癌化疗敏感性较低,存在明显的异质性,传统化疗疗效极其有限。以分子表型为指引的靶向治疗是进一步提高胃癌治疗效果的重要途径。曲妥珠单抗已被证明与化疗联合可以提高初治HER-2阳性胃癌患者的生存。相对于安慰剂,Ramuci-rumab延长了二线治疗患者的生存。抗C-MET单克隆抗体Rilotumumab在Ⅱ期研究中显示出良好的前景。然而,大多数的靶向药物都未能在胃癌的临床研究中获得成功。寻找胃癌关键的靶基因,开发更有效靶向药物仍任重道远。
引用
收藏
页码:1408 / 1412
页数:5
相关论文
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