TrkB在胆管癌中的表达及其临床意义

被引:4
作者
魏伟
汤恢焕
霍胜军
李巨仕
机构
[1] 中南大学湘雅医院普外科
关键词
胆管癌; TrkB; 免疫组化;
D O I
10.13241/j.cnki.pmb.2008.09.056
中图分类号
R735.8 [胆囊、胆道肿瘤];
学科分类号
摘要
目的:研究胆管癌和正常胆管组织中TrkB蛋白的表达及其与临床病理特征的关系。方法:免疫组化检测42例胆管癌和10例正常胆管石蜡切片标本中TrkB蛋白的表达并分析其与临床病理因素的关系。结果:正常胆管组织中无TrkB蛋白的表达,胆管癌组织TrkB蛋白的表达率为69.0%(29/42)。TrkB表达与分化程度、有无淋巴结转移和远处转移有关,而与性别、年龄、肿瘤大小无关。TrkB蛋白在低分化组、有淋巴结转移组和有远处转移组中的表达率均高于高中分化组,无淋巴结转移组和无远处转移组(P<0.05)。结论:TrkB在胆管癌组织中的表达可作为预测胆管癌发生淋巴结转移和远处转移的指标。
引用
收藏
页码:1687 / 1689
页数:3
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