慢性乙型肝炎的疗效预测和优化治疗策略

被引:36
作者
樊蓉
孙剑
侯金林
机构
[1] 南方医科大学南方医院肝病中心和感染内科
关键词
肝炎,乙型,慢性; 干扰素α; 核酸类,核苷酸和核苷类;
D O I
暂无
中图分类号
R512.62 [];
学科分类号
摘要
乙型肝炎抗病毒治疗的药物包括两大类:α-干扰素类和核苷(酸)类似物。目前临床抗病毒方案存在疗效不佳和耐药率高的缺点,而探索预测疗效的指标,并在此基础上优化抗病毒治疗方案提高疗效,降低耐药率成为我国乙型肝炎临床研究的重点。抗病毒药物优化的关键就在于:在适当的时机选择合适的抗病毒药物,并在治疗过程中监测应答情况,对疗效欠佳的患者及时调整治疗方案,以提高远期疗效,降低耐药的发生。在中国制定一套适合我国国情的抗病毒优化治疗策略将是我国乙型肝炎治疗领域亟待解决的重要问题之一。
引用
收藏
页码:1239 / 1244
页数:6
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[1]
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[2]
Factors That Predict Response of Patients With Hepatitis B e Antigen–Positive Chronic Hepatitis B to Peginterferon-Alfa[J] Erik H.C.J. Buster;Bettina E. Hansen;George K.K. Lau;Teerha Piratvisuth;Stefan Zeuzem;Ewout W. Steyerberg;Harry L.A. Janssen Gastroenterology 2009,
[3]
2-Year GLOBE Trial Results: Telbivudine Is Superior to Lamivudine in Patients With Chronic Hepatitis B[J] Yun–Fan Liaw;Edward Gane;Nancy Leung;Stefan Zeuzem;Yuming Wang;Ching Lung Lai;E. Jenny Heathcote;Michael Manns;Natalie Bzowej;Junqi Niu;Steven–Huy Han;Seong Gyu Hwang;Yilmaz Cakaloglu;Myron J. Tong;George Papatheodoridis;Yagang Chen;Nathaniel A. Brown;Efsevia Albanis;Karin Galil;Nikolai V. Naoumov Gastroenterology 2009,
[4]
Baseline characteristics and early on-treatment response predict the outcomes of 2<ce:hsp sp="0.25"/>years of telbivudine treatment of chronic hepatitis B[J] Stefan Zeuzem;Edward Gane;Yun-Fan Liaw;Seng G. Lim;Adrian DiBisceglie;Maria Buti;Anuchit Chutaputti;Jens Rasenack;Jinlin Hou;Christopher O’Brien;Tuan T. Nguyen;Jidong Jia;Thierry Poynard;Bruce Belanger;Weibin Bao;Nikolai V. Naoumov Journal of Hepatology 2009,
[5]
911 PROLONGED EFFICACY AND SAFETY OF 3 YEARS OF CONTINUOUS TELBIVUDINE TREATMENT IN POOLED DATA FROM GLOBE AND 015 STUDIES IN CHRONIC HEPATITIS B PATIENTS[J] C.-W. Hsu;Y.-C. Chen;Y.-F. Liaw;E. Gane;M. Manns;S. Zeuzem;Y. Wang;C.L. Lai;J. Hou;N. Leung;N. Bzowej;J. Niu;J. Jia;S.G. Hwang;Y. Cakaloglu;H. Ren;G. Papatheodoridis;Y. Chen;W. Bao;P. Lopez Journal of Hepatology 2009,
[6]
EASL Clinical Practice Guidelines: Management of chronic hepatitis B[J] European Association for the Study of the Liver Journal of Hepatology 2009,
[7]
Early serum HBsAg drop: A strong predictor of sustained virological response to pegylated interferon alfa‐2a in HBeAg‐negative patients[J] Rami Moucari;Vincent Mackiewicz;Olivier Lada;Marie‐Pierre Ripault;Corinne Castelnau;Michelle Martinot‐Peignoux;Agnes Dauvergne;Tarik Asselah;Nathalie Boyer;Pierre Bedossa;Dominique Valla;Michel Vidaud;Marie‐Hélène Nicolas‐Chanoine;Patrick Marcellin Hepatology 2009,
[8]
Hepatitis B virus surface antigen levels: A guide to sustained response to peginterferon alfa‐2a in HBeAg‐negative chronic hepatitis B[J] Maurizia Rossana Brunetto;Francesco Moriconi;Ferruccio Bonino;George K. K. Lau;Patrizia Farci;Cihan Yurdaydin;Teerha Piratvisuth;Kangxian Luo;Yuming Wang;Stephanos Hadziyannis;Eva Wolf;Philip McCloud;Richard Batrla;Patrick Marcellin Hepatology 2009,
[9]
Report of an International Workshop: Roadmap for Management of Patients Receiving Oral Therapy for Chronic Hepatitis B[J] Emmet B. Keeffe;Stefan Zeuzem;Raymond S. Koff;Douglas T. Dieterich;Rafael Esteban–Mur;Edward J. Gane;Ira M. Jacobson;Seng G. Lim;Nikolai Naoumov;Patrick Marcellin;Teerha Piratvisuth;Fabien Zoulim Clinical Gastroenterology and Hepatology 2007,
[10]
Long-term Therapy With Adefovir Dipivoxil for HBeAg-Negative Chronic Hepatitis B for up to 5 Years[J] Stephanos J. Hadziyannis;Nicolaos C. Tassopoulos;E. Jenny Heathcote;Ting–Tsung Chang;George Kitis;Mario Rizzetto;Patrick Marcellin;Seng Gee Lim;Zachary Goodman;Jia Ma;Carol L. Brosgart;Katyna Borroto–Esoda;Sarah Arterburn;Steven L. Chuck Gastroenterology 2006,