重症患者肠屏障功能检测指标的研究进展

被引：13

作者：

张秉欣

吴建浓

冯丹丹

蒋昭清

机构：

[1] 浙江中医药大学第一临床医学院

来源：

浙江医学 | 2017年 / 39卷 / 13期

关键词：

肠屏障; 重症患者; 检测指标;

D O I：

暂无

中图分类号：

R459.7 [急症、急救处理];

学科分类号：

100231 [临床病理学];

摘要：

重症患者常出现急性胃肠功能损伤,导致肠屏障功能障碍,其与预后密切相关。因此,肠屏障功能的评价越来越受到重视,目前评价方法分体外和体内法。体外方法通过肠组织活检经免疫组化和扫描电子显微镜观察;体内方法通过肠道渗透性试验以及生物标志物评估肠上皮完整性,如肠道细菌代谢产物、肠道内相关酶或蛋白质、细菌标志物如循环内毒素等。本文就近年来肠屏障功能的主要检测指标及其研究进展进行综述。

引用

页码：1127 / 1130

页数：4

共 25 条

[1]

Trefoil Factor Peptides and Gastrointestinal Function.[J].Eitaro Aihara;Kristen A. Engevik;Marshall H. Montrose.Annual Review of Physiology.2017, 1

[2]

LPS Induces Hyper-Permeability of Intestinal Epithelial Cells [J].

Bein, Amir ;

Zilbershtein, Alexander ;

Golosovsky, Michael ;

Davidov, Dan ;

Schwartz, Betty .

JOURNAL OF CELLULAR PHYSIOLOGY, 2017, 232 (02) :381-390

[3]

The complex task of measuring intestinal permeability in basic and clinical science [J].

Galipeau, H. J. ;

Verdu, E. F. .

NEUROGASTROENTEROLOGY AND MOTILITY, 2016, 28 (07) :957-965

[4]

Shenfu injection alleviates intestine epithelial damage in septic rats [J].

Xing, Xi ;

Jiang, Ronglin ;

Wang, Lingcong ;

Lei, Shu ;

Zhi, Yihui ;

Wu, Yanchun ;

Zhu, Meifei ;

Huang, Liquan ;

Xia, Guolian ;

Chen, Zheqi .

AMERICAN JOURNAL OF EMERGENCY MEDICINE, 2015, 33 (11) :1665-1670

[5]

Claudin-2 as a mediator of leaky gut barrier during intestinal inflammation [J].

Luettig, J. ;

Rosenthal, R. ;

Barmeyer, C. ;

Schulzke, J. D. .

TISSUE BARRIERS, 2015, 3 (1-2)

[6]

Plasma biomarkers for early diagnosis of acute intestinal ischemia [J].

Powell, Alexis ;

Armstrong, Paul .

SEMINARS IN VASCULAR SURGERY, 2014, 27 (3-4) :170-175

[7]

The role of serum intestinal fatty acid binding protein levels and D-lactate levels in the diagnosis of acute intestinal ischemia [J].

Shi, Hui ;

Wu, Benyan ;

Wan, Jun ;

Liu, Wenhui ;

Su, Binbin .

CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY, 2015, 39 (03) :373-378

[8]

D-lactate is a valid biomarker of intestinal ischemia induced by abdominal compartment syndrome [J].

Nielsen, Casper ;

Kirkegard, Jakob ;

Erlandsen, Erland J. ;

Lindholt, Jes S. ;

Mortensen, Frank V. .

JOURNAL OF SURGICAL RESEARCH, 2015, 194 (02) :400-404

[9]

Can Intestinal Fatty Acid Binding Protein (I-FABP) Be A Marker in the Diagnosis of Abdominal Pathology?.[J].Ozlem UZUN;Suha TURKMEN;Umut ERYIGIT;Ahmet MENTESE;Serdar TURKYILMAZ;Suleyman TUREDI;Suleyman Caner KARAHAN;Abdulkadir GUNDUZ.Turkish Journal of Emergency Medicine.2014, 3

[10]

Plasma Intestinal Fatty Acid–Binding Protein Levels Correlate With Morphologic Epithelial Intestinal Damage in a Human Translational Ischemia-reperfusion Model.[J].Dirk H. S. M. Schellekens;Joep Grootjans;Simon A. W. G. Dello;Annemarie A. van Bijnen;Ronald M. van Dam;Cornelis H. C. Dejong;Joep P. M. Derikx;Wim A. Buurman.Journal of Clinical Gastroenterology.2014, 3

← 1 2 3 →