增生性瘢痕中成纤维细胞向肌成纤维细胞转化的影响因素研究

被引：12

作者：

黎荣珍 ^{[1
]}

刘毅 ^{[2
]}

机构：

[1] 兰州大学第二临床医学院

[2] 解放军联勤保障部队第医院(原兰州军区总医院)全军烧伤整形外科中心

来源：

中国美容医学 | 2019年 / 28卷 / 06期

关键词：

增生性瘢痕; 成纤维细胞; 肌成纤维细胞; TGF-β1;

D O I：

10.15909/j.cnki.cn61-1347/r.003120

中图分类号：

R622 [整形手术学];

学科分类号：

100224 [整形外科学];

摘要：

肌成纤维细胞（myofibroblast,MFB）是增生性瘢痕（hypertrophic scar,HS）形成过程中重要的效应细胞,因此TGF-β1（transforming growth factor-β1）介导的成纤维细胞（fibroblast,FB）向MFB的转化可成为预防HS的一个重要靶点。近年来,有很多关于人瘢痕组织内FB向MFB转化的影响因素的研究,旨在通过调控这些影响因素抑制该环节的发生,从而更有针对性地预防HS形成。本文就人瘢痕组织内FB向MFB转化的影响因素研究进展综述如下。

引用

页码：164 / 167

页数：4

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