胱抑素C与冠心病的相关性研究

被引：25

作者：

孙磊 ^{[1
,2
]}

杨志健 ^{[1
]}

贾恩志 ^{[1
]}

机构：

[1] 南京医科大学第一附属医院心内科

[2] 苏北人民医院心内科

来源：

南京医科大学学报(自然科学版) | 2009年 / 29卷 / 05期

关键词：

胱抑素; 冠状动脉疾病; 冠状动脉造影;

D O I：

暂无

中图分类号：

R541.4 [冠状动脉（粥样）硬化性心脏病（冠心病）];

学科分类号：

1002 ; 100201 ;

摘要：

目的:研究血清胱抑素C(CysC)与冠心病的相关性。方法:回顾性分析525例高度怀疑冠心病而行冠脉造影患者的临床资料,从冠心病病情程度、冠脉病变支数和冠脉病变Gensini总积分3方面研究血清CysC水平与冠心病之间的关系。应用免疫比浊法检测血清CysC浓度,对CysC水平与冠心病病情、冠脉病变程度和冠脉病变Gensini总积分进行单因素和多因分析。结果:①随着血清CysC水平的升高,冠心病患者病情逐渐加重,冠脉病变支数和Gensini总积分增加;在急性心梗时由于急性时相反应血清CysC水平出现下降;②Logistic回归结果显示CysC与冠脉有无病变显著相关(OR值5.346,95%CI为2.225～12.846,P<0.01);③多元逐步回归结果显示在校正了年龄、性别等因素之后,CysC与冠脉病变Gensini总积分(β=0.149,P<0.01)仍然独立相关。结论:血清CysC水平与冠心病有密切关系。随着血清CysC水平升高,冠心病患者病情逐渐加重,冠脉病变程度也更加严重。

引用

页码：702 / 706+731 +731

页数：6

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