TGF-β/Smads信号通路与胰腺纤维化

被引：7

作者：

姜婷婷

许小凡

张红

机构：

[1] 陕西中医学院基础医学院

来源：

中华临床医师杂志(电子版) | 2013年 / 7卷 / 24期

关键词：

胰腺; 纤维化; 星形细胞; 转化生长因子β; Smad蛋白质类;

D O I：

暂无

中图分类号：

R576 [胰腺疾病];

学科分类号：

100201 [内科学];

摘要：

胰腺星状细胞(PSC)是胰腺纤维化发生发展的关键细胞,转化生长因子β(TGF-β)是促进PSC活化以及细胞外基质合成的主要因子。TGF-β/Smads信号转导通路在PSC活化、进而在胰腺纤维化形成中具有重要的作用,本文着重就TGF-β/Smads信号转导通路在胰腺纤维化中的分子机制做一综述。

引用

页码：11619 / 11622

页数：4

共 15 条

[1]

Transforming growth factor-β signalling: Role and consequences of Smad linker region phosphorylation [J].

Kamato, Danielle ;

Burch, Micah L. ;

Piva, Terrence J. ;

Rezaei, Hossein Babaahmadi ;

Rostam, Muhamad Ashraf ;

Xu, Suowen ;

Zheng, Wenhua ;

Little, Peter J. ;

Osman, Narin .

CELLULAR SIGNALLING, 2013, 25 (10) :2017-2024

[2]

Anti-fibrotic effect of Cordyceps sinensis polysaccharide: Inhibiting HSC activation, TGF-β1/Smad signalling, MMPs and TIMPs [J].

Peng, Jinghua ;

Li, Xuemei ;

Feng, Qin ;

Chen, Liang ;

Xu, Lili ;

Hu, Yiyang .

EXPERIMENTAL BIOLOGY AND MEDICINE, 2013, 238 (06) :668-677

[3]

The TGFbeta Superfamily Signaling Pathway [J].

Weiss, Alexander ;

Attisano, Liliana .

WILEY INTERDISCIPLINARY REVIEWS-DEVELOPMENTAL BIOLOGY, 2013, 2 (01) :47-63

[4]

Chronic pancreatitis [J].

Braganza, Joan M. ;

Lee, Stephen H. ;

McCloy, Rory F. ;

McMahon, Michael J. .

LANCET, 2011, 377 (9772) :1184-1197

[5]

Role of Smads in TGFβ signaling [J].

Heldin, Carl-Henrik ;

Moustakas, Aristidis .

CELL AND TISSUE RESEARCH, 2012, 347 (01) :21-36

[6]

Transforming growth factor (TGF)-β signaling in cardiac remodeling.[J].Marcin Dobaczewski;Wei Chen;Nikolaos G. Frangogiannis.Journal of Molecular and Cellular Cardiology.2010, 4

[7]

Signal transduction in pancreatic stellate cells [J].

Masamune, Atsushi ;

Shimosegawa, Tooru .

JOURNAL OF GASTROENTEROLOGY, 2009, 44 (04) :249-260

[8]

Mechanisms of pancreatic fibrosis and applications to the treatment of chronic pancreatitis [J].

Shimizu, Kyoko .

JOURNAL OF GASTROENTEROLOGY, 2008, 43 (11) :823-832

[9]

Fetal and Adult Fibroblasts Have Similar TGF-β–Mediated; Smad-Dependent Signaling Pathways.[J].Amy S. Colwell;Thomas M. Krummel;Michael T. Longaker;H Peter Lorenz.Plastic and Reconstructive Surgery.2006, 7

[10]

Angiotensin II promotes the proliferation of activated pancreatic stellate cells by Smad7 induction through a protein kinase C pathway.[J].Kouji Hama;Hirohide Ohnishi;Hiroyoshi Aoki;Hiroto Kita;Hironori Yamamoto;Hiroyuki Osawa;Kiichi Sato;Kiichi Tamada;Hirosato Mashima;Hiroshi Yasuda;Kentaro Sugano.Biochemical and Biophysical Research Communications.2005, 3

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