NLRP3炎症小体在肝纤维化形成中作用的研究进展

被引：12

作者：

李凡 ^{[1
]}

白纪红 ^{[2
]}

梁志清 ^{[2
]}

机构：

[1] 桂林医学院

[2] 桂林医学院附属医院

来源：

山东医药 | 2018年 / 58卷 / 08期

关键词：

肝纤维化; 炎症小体; 细胞焦亡; 肝星状细胞; 枯否细胞; 巨噬细胞;

D O I：

暂无

中图分类号：

R575.2 [肝硬变];

学科分类号：

100201 [内科学];

摘要：

肝纤维化是一种各种原因所致慢性肝损伤的愈合应答反应,如果持续存在将导致肝硬化甚至肝癌。炎症反应是肝纤维化发生、发展过程中的重要因素。NLRP3炎症小体是一种细胞内多蛋白复合物,作为炎症反应关键的调节及转录因子,可诱导促炎因子的活化和释放;还能通过识别细胞内外的危险信号,释放促炎因子,诱发细胞焦亡。因此,NLRP3炎症小体在肝纤维化形成过程中具有重要作用。

引用

收藏

页码：98 / 100

页数：3

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共 12 条

[1]

Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases [J].

Man, Si Ming ;

Karki, Rajendra ;

Kanneganti, Thirumala-Devi .

IMMUNOLOGICAL REVIEWS, 2017, 277 (01) :61-75

[2]

Regulation of inflammasome activation [J].

Man, Si Ming ;

Kanneganti, Thirumala-Devi .

IMMUNOLOGICAL REVIEWS, 2015, 265 (01) :6-21

[3]

Activation of NLRP3 and AIM2 inflammasomes in Kupffer cells in hepatic ischemia/reperfusion [J].

Kim, Hyo-Yeon ;

Kim, Seok-Joo ;

Lee, Sun-Mee .

FEBS Journal, 2015, 282 (02) :259-270

[4]

P2X7 blockade attenuates mouse liver fibrosis [J].

Huang, Changshan ;

Yu, Wei ;

Cui, Hong ;

Wang, Yunjian ;

Zhang, Ling ;

Han, Feng ;

Huang, Tao .

MOLECULAR MEDICINE REPORTS, 2014, 9 (01) :57-62

[5]

Mechanisms and Functions of Inflammasomes [J].

Lamkanfi, Mohamed ;

Dixit, Vishva M. .

CELL, 2014, 157 (05) :1013-1022

[6]

Constitutive NLRP3 Activation: Too Much of a Bad Thing [J].

Mehal, Wajahat Z. .

HEPATOLOGY, 2014, 59 (03) :761-763

[7]

NLRP3 Inflammasome Activation Results in Hepatocyte Pyroptosis, Liver Inflammation, and Fibrosis in Mice [J].

Wree, Alexander ;

Eguchi, Akiko ;

McGeough, Matthew D. ;

Pena, Carla A. ;

Johnson, Casey D. ;

Canbay, Ali ;

Hoffman, Hal M. ;

Feldstein, Ariel E. .

HEPATOLOGY, 2014, 59 (03) :898-910

[8]

IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice [J].

Petrasek, Jan ;

Bala, Shashi ;

Csak, Timea ;

Lippai, Dora ;

Kodys, Karen ;

Menashy, Victoria ;

Barrieau, Matthew ;

Min, So-Yun ;

Kurt-Jones, Evelyn A. ;

Szabo, Gyongyi .

JOURNAL OF CLINICAL INVESTIGATION, 2012, 122 (10) :3476-3489

[9]

Inflammasomes in liver diseases [J].

Szabo, Gyongyi ;

Csak, Timea .

JOURNAL OF HEPATOLOGY, 2012, 57 (03) :642-654

[10]

Biochemical regulation of the inflammasome [J].

Dowling, Jennifer K. ;

O'Neill, Luke A. J. .

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2012, 47 (05) :424-443