利塞膦酸钠与羟磷酸盐联合应用治疗绝经后骨质疏松症的实验研究

被引:2
作者
李蔚 [1 ]
马嘉 [1 ]
张妍 [1 ]
倪跃 [2 ]
机构
[1] 解放军医院
[2] 安徽医科大学
关键词
利塞膦酸钠; 羟磷酸盐; 骨质疏松症;
D O I
暂无
中图分类号
R580 [];
学科分类号
摘要
目的观察和分析利塞膦酸钠与羟磷酸盐联合应用对绝经后骨质疏松家兔的治疗作用。方法观测利塞膦酸钠及利塞膦酸钠与羟磷酸盐联合应用对实验性绝经后骨质疏松家兔血清碱性磷酸酶活性、血钙、血磷、股骨骨密度及骨小梁宽度的影响。结果与单独使用利塞膦酸钠组相比,利塞膦酸钠与羟磷酸盐联合应用可明显增加绝经后骨质疏松家兔血钙值(P<0.01),血磷值(P<0.05),股骨骨密度及骨小梁宽度的测定与对照组相比差异有统计学意义(P<0.01),血清ALP无明显差异(P>0.05)。结论利塞膦酸钠与羟磷酸盐联合应用对绝经后骨质疏松家兔有明显的治疗作用。
引用
收藏
页码:474 / 475
页数:2
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