再生障碍性贫血病因学的新探索:异常免疫诱导骨髓间充质干细胞的过度脂肪化(英文)

被引：25

作者：

卢学春 ^{[1
]}

杨波 ^{[1
]}

迟小华 ^{[2
]}

于睿莉 ^{[3
]}

机构：

[1] Department of Geriatric Hematology,Chinese PLA General Hospital

[2] Department of Pharmacy,Second Artillery General Hospital

[3] Department of Otorhinolaryngology,West Division of Beijing Chao-Yang Hospital

来源：

解放军医学杂志 | 2014年 / 39卷 / 03期

关键词：

贫血,再生障碍性; 间质干细胞; 脂细胞;

D O I：

暂无

中图分类号：

R556.5 [再生障碍性贫血和骨髓硬化性贫血];

学科分类号：

100201 [内科学];

摘要：

再生障碍性贫血(简称再障)是一种以血细胞减少为表现的疾病。骨髓脂肪过多且造血前体细胞减少是其显著骨髓病理学特征。本文解读和分析了与再障和脂肪细胞相关的论著和关键综述,旨在对骨髓脂肪细胞在再障发病中的作用进行初步探索。这些文献提示,再障相关性毒素和毒性药物,一般也具有诱导骨髓间充质干细胞向脂肪细胞分化的作用。再障的免疫治疗反应时间要远远长于典型免疫相关性血细胞减少症,表明异常免疫的靶细胞不仅仅是造血干/祖细胞,骨髓间充质干细胞也可能也受累。免疫抑制剂和雄激素治疗再障有效,二者也具有抑制骨髓间充质干细胞向脂肪细胞分化的作用。脂肪细胞分泌的很多细胞因子均有抑制骨髓造血作用,包括肿瘤坏死因子(TNF-α),白细胞介素6(IL-6)和干扰素γ(IFN-γ)。动物模型也证实,骨髓过度脂肪化可抑制造血。另外,获得性再生障碍性贫血一般被视作一种免疫介导的疾病,包括免疫细胞和分子介导造血干/祖细胞破坏导致骨髓造血衰竭。综上,骨髓内间充质干细胞向脂肪细胞过度分化可能是再障发病的新的病理学机制之一。

引用

页码：173 / 179

页数：7

共 16 条

[1]

氯化锂联合环孢素A对再生障碍性贫血小鼠的治疗作用.[J].张娜;代玉龙;黄丽芳;刘文励;.中国实验血液学杂志.2012, 03

[2]

Cotransplantation of haploidentical hematopoietic and umbilical cord mesenchymal stem cells for severe aplastic anemia: Successful engraftment and mild GVHD [J].

Wu Yamei ;

Cao Yongbin ;

Li Xiaohong ;

Xu Lixin ;

Wang Zhihong ;

Liu Pei ;

Yan Pei ;

Liu Zhouyang ;

Wang Jing ;

Jiang Shuang ;

Wu Xiaoxiong ;

Gao Chunji ;

Da Wanming ;

Han Zhongchao .

STEM CELL RESEARCH, 2014, 12 (01) :132-138

[3]

Downregulation of GATA-2 and overexpression of adipogenic gene-PPARγ in mesenchymal stem cells from patients with aplastic anemia [J].

Xu, Yinyan ;

Takahashi, Yoshiyuki ;

Wang, Yue ;

Hama, Asahito ;

Nishio, Nobuhiro ;

Muramatsu, Hideki ;

Tanaka, Makito ;

Yoshida, Nao ;

Villalobos, Itzel Bustos ;

Yagasaki, Hiroshi ;

Kojima, Seiji .

EXPERIMENTAL HEMATOLOGY, 2009, 37 (12) :1393-1399

[4]

Interleukin-15 increases calcineurin expression in 3T3-L1 cells: Possible involvement on in vivo adipocyte differentiation [J].

Almendro, Vanessa ;

Fuster, Gemma ;

Ametller, Elisabet ;

Costelli, Paola ;

Pilla, Federica ;

Busquets, Silvia ;

Figueras, Maite ;

Argiles, Josep M. ;

Lopez-Soriano, Francisco J. .

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2009, 24 (04) :453-458

[5]

Effects of dihydrotestosterone on differentiation and proliferation of human mesenchymal stem cells and preadipocytes.[J].Vandana Gupta;Shalender Bhasin;Wen Guo;Rajan Singh;Rika Miki;Pratibha Chauhan;Karen Choong;Tamara Tchkonia;Nathan K. Lebrasseur;John N. Flanagan;James A. Hamilton;Jason C. Viereck;Navjot S. Narula;James L. Kirkland;Ravi Jasuja.Molecular and Cellular Endocrinology.2008, 1

[6]

Hematopoietic growth factors in the treatment of acquired bone marrow failure states [J].

Marsh, Judith C. W. ;

Ganser, Arnold ;

Stadler, Michael .

SEMINARS IN HEMATOLOGY, 2007, 44 (03) :138-147

[7]

Induction of c-Fos and NFATc1 during RANKL-stimulated osteoclast differentiation is mediated by the p38 signaling pathway [J].

Huang, Hao ;

Chang, Eun-Ju ;

Ryu, Jiyoon ;

Lee, Zang Hee ;

Lee, Youngkyun ;

Kim, Hong-Hee .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 351 (01) :99-105

[8]

Long-term outcome in acquired aplastic anemia treated with an intensified dose schedule of horse antilymphocyte globulin in combination with androgens [J].

Leleu, Xavier ;

Terriou, Louis ;

Duhamel, Alain ;

Moreau, Anne-Sophie ;

Andrieux, Joris ;

Dupire, Sophie ;

Coiteux, Valerie ;

Berthon, Celine ;

Micol, Jean-Baptiste ;

Guieze, Romain ;

Facon, Thierry ;

Bauters, Francis .

ANNALS OF HEMATOLOGY, 2006, 85 (10) :711-716

[9]

T-cell suppression mediated by mesenchymal stem cells is deficient in patients with severe aplastic anemia [J].

Bacigalupo, A ;

Valle, M ;

Podestà, M ;

Pitto, A ;

Zocchi, E ;

De Flora, A ;

Pozzi, S ;

Luchetti, S ;

Frassoni, F ;

Van Lint, MT ;

Piaggio, G .

EXPERIMENTAL HEMATOLOGY, 2005, 33 (07) :819-827

[10]

Recombinant methionyl human leptin administration activates signal transducer and activator of transcription 3 signaling in peripheral blood mononuclear cells in vivo and regulates soluble tumor necrosis factor-α receptor levels in humans with relative leptin deficiency [J].

Chan, JL ;

Moschos, SJ ;

Bullen, J ;

Heist, K ;

Li, X ;

Kim, YB ;

Kahn, BB ;

Mantzoros, CS .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (03) :1625-1631

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