MAPK信号通路与神经系统损伤的研究进展

被引：42

作者：

陶昕 ^{[1
]}

孟祥志 ^{[1
]}

孙丽 ^{[2
]}

于丽 ^{[2
]}

机构：

[1] 潍坊医学院临床医学系

[2] 潍坊医学院组织学与胚胎学教研室

来源：

解剖科学进展 | 2010年 / 16卷 / 06期

关键词：

D O I：

10.16695/j.cnki.1006-2947.2010.06.011

中图分类号：

R346 [];

学科分类号：

摘要：

丝裂酶原活化蛋白激酶(Mitogen-activated protein kinase,MAPK)是生物体内重要的信号转导通路之一,主要有ERK、p38和JNK三条途径,参与调控多种细胞应答和生理病理过程。ERK和p38在神经损伤的区域迅速激活,减少神经损伤对机体带来的影响;磷酸化JNK在神经损伤部位聚集,促进神经细胞的凋亡,加重神经损伤发生的过程。MAPK信号通路与神经系统损伤的发生、修复存在着紧密的联系

引用

页码：574 / 577+582 +582

页数：5

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