H型高血压的病因及发病机制

被引:67
作者
张明玺 [1 ]
罗俊 [2 ]
机构
[1] 湖北丹江口市第一医院心内科
[2] 成都市第三人民医院心血管疾病研究所
关键词
H型高血压; 高同型半胱氨酸; 发病机制;
D O I
暂无
中图分类号
R544.1 [高血压];
学科分类号
1002 ; 100201 ;
摘要
H型高血压在我国发病率很高。其同型半胱氨酸水平与年龄、性别、人种、营养及合并疾病等多个因素有关;发病机制涉及到血管内皮细胞功能障碍、血管平滑肌细胞增殖、血脂异常、凝血系统异常及胰岛素抵抗等多个方面。理解这些基本影响因素,将为H型高血压的防治起到重要作用。
引用
收藏
页码:253 / 256
页数:4
相关论文
共 14 条
[1]   高同型半胱氨酸血症治疗研究进展 [J].
程丝 ;
冯娟 ;
王宪 .
生理科学进展, 2011, 42 (05) :329-334
[2]   马来酸依那普利叶酸片降压、降同型半胱氨酸的疗效和安全性 [J].
李建平 ;
霍勇 ;
刘平 ;
秦献辉 ;
关德明 ;
葛均波 ;
胡健 ;
王燕妮 ;
张馥敏 ;
毛广运 ;
徐希平 .
北京大学学报(医学版), 2007, (06) :614-618
[3]   高同型半胱氨酸血症致血管内皮功能障碍研究进展 [J].
加娜提 ;
张向阳 .
心血管病学进展, 2007, (02) :315-317
[4]  
Pronounced association of elevated serum homocysteine with stroke in subgroups of individuals: A nationwide study[J] . Amytis Towfighi,Daniela Markovic,Bruce Ovbiagele.Journal of the Neurological Sciences . 2010 (1)
[5]   The use of an in vivo model to study the effects of hyperhomocysteinaemia on vascular function [J].
Hansrani, Monica ;
Stansby, Gerard ;
Cantab, M. A. ;
Chir, M. .
JOURNAL OF SURGICAL RESEARCH, 2008, 145 (01) :13-18
[6]   Chronic apoptosis of vascular smooth muscle cells accelerates atherosclerosis and promotes calcification and medial degeneration [J].
Clarke, Murray C. H. ;
Littlewood, Trevor D. ;
Figg, Nichola ;
Maguire, Janet J. ;
Davenport, Anthony P. ;
Goddard, Martin ;
Bennett, Martin R. .
CIRCULATION RESEARCH, 2008, 102 (12) :1529-1538
[7]  
Relationship of homocysteine to markers of platelet and endothelial activation in ‘high risk’ hypertensives: a substudy of the Anglo-Scandinavian Cardiac Outcomes Trial[J] . Charles G.C. Spencer,Steven C. Martin,Dirk C. Felmeden,Andrew D. Blann,Gareth D. Beevers,Gregory Y.H. Lip.International Journal of Cardiology . 2004 (2)
[8]  
Polygenic influence on plasma homocysteine: association of two prevalent mutations, the 844ins68 of cystathionine β-synthase and A 2756 G of methionine synthase, with lowered plasma homocysteine levels[J] . Michael Y Tsai,Michelle Bignell,Feng Yang,Barry G Welge,Kevin J Graham,Naomi Q Hanson.Atherosclerosis . 2000 (1)
[9]  
Plasma Homocysteine, Aortic Stiffness, and Renal Function in Hypertensive Patients[J] . Luiz A. Bortolotto,Michel E. Safar,Eliane Billaud,Christian Lacroix,Roland Asmar,Gérard M. London,Jacques Blacher.Hypertension . 1999 (4, P)
[10]   Role of oxidant stress in endothelial dysfunction produced by experimental hyperhomocyst(e)inemia in humans [J].
Kanani, PM ;
Sinkey, CA ;
Browning, RL ;
Allaman, M ;
Knapp, HR ;
Haynes, WG .
CIRCULATION, 1999, 100 (11) :1161-1168