凝血试验真空管“死腔”所致APTT、PF4偏差探讨

被引：20

作者：

丛玉隆

吴丽媛

殷宗健

机构：

[1] 中国人民解放军总医院临床检验科

[2] 美国BD公司技术部

来源：

临床检验杂志 | 2002年 / 05期

关键词：

死腔; APTT; PF4因子;

D O I：

10.13602/j.cnki.jcls.2002.05.002

中图分类号：

R446.11 [血液学检验];

学科分类号：

摘要：

目的　探讨“有死腔”凝血试验管收集的血样进行血小板功能和肝素治疗患者APTT结果的偏差及机制。方法　将 2 0例肝素治疗心肌梗死患者血液分别收集在无或能形成死腔的采血管中 ,分别进行APTT和PF4检测。结果　“有死腔”的采血管使7例患者APTT结果缩短 ,PF4活性增强。结论　采血管死腔增加了血小板与管壁或死腔气体的接触而激活血小板 ,释放PF4并中和肝素 ,造成APTT负偏差。建议进行血小板功能试验或APTT用于肝素治疗监测时使用“无死腔”真空采血管

引用

页码：263 / 264

页数：2

共 8 条

[1]

Joist J,Eyers T.Laboratory Monitoring of heparin Therapy. Thrombosis Forum . 1995

[2]

Brill-Edwards P,Ginsberg JS,Johnston M,et al.Establishing a therapeutic range for heparin therapy. Annals of Internal Medicine . 1993

[3]

Sandrick K.Partial drawback: iffy APTTs lead to tube s exist. CAP Today College of American Pathologists . 2000

[4]

Rosborough TK.Comparison of Anti-factor Xa heparin Activity and Activated Partial Thromboplatin Time in 2773 Plasma Samples from Unfractionated Heparin-treated patients. American Journal of Clinical Pathology . 1997

[5]

Nelson DE.Current Considerations in the use of the APTT in Monitoring Unfractionated Heparin. Clinical Laboratory . 1999

[6]

Triplett DA,Brandt JT.Laboratory Monitoring of Heparin Therapy. Hemoliance Times . 1997

[7]

Strekerud FG,Abildgaard U.Activated partial thromboplastin time in heparinized plasma: influence of reagent, acute-phase reaction and interval between sampling and testing. Clin Appl Thromb Hemostasis . 1996

[8]

Jamie SJE,Bernard DW,Swami VK,et al.Monitoring heparin therapy: APTT results from partial-vs full-draw tubes. American Journal of Clinical Pathology Aug . 1998

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