缓激肽选择性开放血脑屏障的机制探讨

被引：8

作者：

黄浩

陈临溪

机构：

[1] 南华大学药物药理研究所

来源：

肿瘤药学 | 2011年 / 1卷 / 04期

关键词：

缓激肽; 血脑屏障; 血瘤屏障; 紧密连接;

D O I：

暂无

中图分类号：

R739.4 [神经系肿瘤];

学科分类号：

100115 [医学神经生物学];

摘要：

血脑屏障在保护大脑的同时也限制了药物的转运。而脑肿瘤患者,其血脑屏障功能虽然不全,但脑肿瘤与血管之间存在血脑肿瘤屏障,很大程度上限制了化疗药物进入脑肿瘤组织。因此,在化疗时,提高血脑肿瘤屏障的通透性是提高化疗药物治疗效果的关键。本文就血脑屏障和血肿瘤屏障的结构特点、功能,以及缓激肽对血肿瘤屏障选择性开放的机制等研究进展做一综述。

引用

页码：330 / 333

页数：4

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