环境致癌物诱导慢性炎症致肺癌发生发展的研究进展

被引:28
作者
吕建祎
张敏
金红蕾
竹俊兰
危金龙
代佳
黄海山
高基民
机构
[1] 温州医科大学检验医学院/生命科学学院,浙江省模式生物技术与应用重点实验室
关键词
环境致癌物; 炎症; 恶性转化; 肺癌;
D O I
暂无
中图分类号
R734.2 [肺肿瘤];
学科分类号
100117 [系统生物医学];
摘要
近年来,由于工业发展负面影响造成的环境污染及吸烟等不良嗜好导致吸入人体肺部的致癌物急剧增加,致使肺癌的发病率及死亡率逐年升高,已跃居各癌症之首.研究表明,环境致癌物诱导肺部慢性炎症与肺癌的发生发展之间存在着紧密联系,环境致癌物如砷、镍及苯并芘等暴露可激活NFAT、NF-κB、AP-1等转录因子,调控炎症因子如TNFα及COX-2等的表达,且这些炎性因子的释放又可正反馈激活转录因子,促进更多的炎性因子产生,进而形成炎性因子产生回路,维持肺部炎性微环境,从而促进肺癌的发生发展.本文就环境致癌物诱导肺部炎症导致肺癌发生发展的分子机制及其相关信号通路进行了综述.
引用
收藏
页码:41 / 51
页数:11
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