THE RELATIONSHIP BETWEEN ULCER RECURRENCE AND HELICOBACTER PYLORI: A PROSPECTIVE ONE-YEAR FOLLOW-UP STUDY IN CHINA

To study the relationship between ulcer recurrence and \%Helicobacter Pylori\%. 147 patients with peptic ulcer were divided into \%H. Pylori\% infected group and \%H.pylori\% uninfected group by rapid urease test、serum antibody examination and histopathology of gastric biopsy specimens. We assigned all patients to receive dual oral therapy with omeprazole 40 mg/day for 4 weeks and amoxicillin 2000 mg/day for 2 weeks. To all patients, repeated gastroscope was performed at 8 weeks and one year after beginning therapy to record whether the ulcer was cured. Endoscopic biopsy was also performed to dertermine \%H.pylori\% status. One year later, \%H.pylori\% positive patients had a higher ulcer recurrent rate than \%H.pylori\% negative patients(23.33% vs 2.70%; P=0.001). Ulcer recurrence was closely related to \%H.pylori\% infection. \%H.pylori\% was the risk factor for ulcer relapse.