姜黄素联合抗TfR抗体体外抗胶质瘤效应研究

被引：4

作者：

文雪

机构：

[1] 湖北职业技术学院护理学院

来源：

免疫学杂志 | 2016年 / 32卷 / 04期

关键词：

姜黄素; 胶质瘤; 转铁蛋受体;

D O I：

10.13431/j.cnki.immunol.j.20160063

中图分类号：

R739.41 [颅内肿瘤及脑肿瘤];

学科分类号：

100115 [医学神经生物学];

摘要：

目的探讨抗转铁蛋白受体(Tf R)抗体联合化疗药物姜黄素的抗瘤效应。方法利用MTT方法检测Tf R抗体与姜黄素单独及联合作用对胶质瘤细胞生存率的影响;利用流式细胞仪检测Tf R抗体与姜黄素单独及联合作用对胶质瘤细胞凋亡、细胞增殖和细胞周期的影响。结果 Tf R抗体与姜黄素联合作用可增强对胶质瘤细胞增殖的抑制作用,促进肿瘤细胞坏死,并将肿瘤细胞有效阻滞在S期。结论抗Tf R抗体可协同增强姜黄素对胶质瘤细胞的生长抑制效应。

引用

页码：320 / 323

页数：4

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