基质金属蛋白酶及其抑制物表达平衡失调与心肌梗塞后心室重塑

被引：13

作者：

郭文安

杜心清

机构：

[1] 福建医科大学附属第二医院心内科

来源：

心血管康复医学杂志 | 2007年 / 03期

关键词：

基质金属蛋白酶类; 心肌梗塞; 心室重构;

D O I：

暂无

中图分类号：

R542.22 [];

学科分类号：

摘要：

基质金属蛋白酶(Matrix metaloproteinases,MMPs)是细胞外基质降解过程中的重要酶类,组织金属蛋白酶抑制物(Tissue matrix metalloproteinase inhibitors,TIMPs)是MMPs的内源性抑制系统。近来研究表明MMPs、TIMPs与心肌梗塞后心室重塑密切相关。现就MMPs/TIMPs平衡失调对心肌梗塞后心室重塑的影响及TIMPs抗心室重塑治疗的研究进展作一综述。

引用

页码：302 / 305

页数：4

共 5 条

[1]

Matrix metalloproteinase-7 affects connexin-43 levels, electrical conduction, and survival after myocardial infarction [J].

Lindsey, ML ;

Escobar, P ;

Mukherjee, R ;

Goshorn, DK ;

Sheats, NJ ;

Bruce, JA ;

Mains, IM ;

Hendrick, JK ;

Hewett, KW ;

Gourdie, RG ;

Matrisian, LM ;

Spinale, FG .

CIRCULATION, 2006, 113 (25) :2919-2928

[2]

Preservation of cardiac extracellular matrix by passive myocardial restraint - An emerging new therapeutic paradigm in the prevention of adverse remodeling and progressive heart failure [J].

Shah, PK .

CIRCULATION, 2005, 112 (09) :1245-1247

[3]

Matrix metalloproteinase inhibition modifies left ventricular remodeling after myocardial infarction in pigs [J].

Yarbrough, WM ;

Mukherjee, R ;

Brinsa, TA ;

Dowdy, KB ;

Scott, AA ;

Escobar, GP ;

Joffs, C ;

Lucas, DG ;

Crawford, FA ;

Spinale, FG .

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2003, 125 (03) :602-610

[4]

Remodeling of the Myocardium and Potential Targets in the Collagen Degradation and Synthesis Pathways.[J].Bodh I. Jugdutt.Current Drug Target -Cardiovascular & Hematologic.2003, 1

[5]

Matrix metalloproteinase expression in cardiac myocytes following myocardial infarction in the rabbit [J].

Romanic, AM ;

Burns-Kurtis, CL ;

Gout, B ;

Berrebi-Bertrand, I ;

Ohlstein, EH .

LIFE SCIENCES, 2001, 68 (07) :799-814

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