胰高血糖素样肽-1受体靶向药物研究进展

被引:3
作者
李彩娜
申竹芳
机构
[1] 中国医学科学院北京协和医学院药物研究所
关键词
胰高血糖素样肽-1受体; 靶向药物; exenatide; liraglutide;
D O I
暂无
中图分类号
R977.15 [];
学科分类号
摘要
胰高血糖素样肽-1(Glucagon-like peptide-1,GLP-1)是一种肠道L细胞分泌的肠降糖素,由30个氨基酸组成。GLP-1与受体结合后具有一定的抗糖尿病作用,但其体内半衰期短(约2min),临床应用受限。GLP-1受体是目前开发抗糖尿病药物的新靶点之一,旨在寻找可以同时激动GLP-1受体和耐受二肽基肽酶IV降解的长效肽类或非肽类化合物。目前该类多肽中exenatide已被美国食品药品管理局批准上市,liraglutide等处于临床研究阶段,尚有很多肽类或非肽类化合物处于临床前研究阶段。文中将近几年来靶向GLP-1受体的研究成果综述如下。
引用
收藏
页码:2219 / 2222+2232 +2232
页数:5
相关论文
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