乙醇对狗急性低氧性肺血管收缩反应的影响——白三烯的作用

被引：1

作者：

卢传义

王迪浔

余尚兵

机构：

[1] 同济医科大学病理生理学教研室,同济医科大学病理生理学教研室,同济医科大学病理生理学教研室武汉,武汉,武汉

来源：

中国应用生理学杂志 | 1992年 / 03期

关键词：

乙醇; 缺氧; 肺血管; 肺动脉高压;

D O I：

10.13459/j.cnki.cjap.1992.03.004

中图分类号：

学科分类号：

摘要：

本实验采用急性胃内灌注乙醇的方法,观察了乙醇对狗血流动力学和低氧性肺血管收缩反应（HPV）的影响,同时探讨了白三烯（LTs）在其中的作用。结果表明:①给乙醇（0.5g/kg）后肺血管阻力（PVR）和平均肺动脉压(pa)显著升高,用脂氧化酶抑制剂特异性地抑制白三烯的合成后,乙醇引起的PVR和pa升高不显著,表明LTs介导乙醇引起的肺血管收缩反应。②给乙醇后HPV显著增强.急性低氧性肺动脉高压明显加重,用脂氧化酶抑制剂特异性地抑制LTs的合成后.乙醇增强HPV的效应被抑制.表明LTs在乙醇增强HPV的效应中起介导作用。实验结果提示饮酒不利于低氧性肺动脉高压、肺心病和高原性心脏病的防治。

引用

页码：15 / 18

页数：4

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