生化标志物在骨质疏松诊断、骨折预测和疗效观察中的应用

被引:11
作者
杨成宇
阮祥燕
刘忠厚
机构
[1] 北京妇产医院
[2] 中国老年学学会骨质疏松委员会
关键词
骨质疏松; 重吸收; 骨形成; 骨标志物; 骨流失; BMD; 生化标志物;
D O I
暂无
中图分类号
R58 [内分泌腺疾病及代谢病];
学科分类号
1002 ; 100201 ;
摘要
<正> 近20年来,骨代谢的生化标志物方面的研究取得了很大进展,许多新的更敏感的指标被发现,并被应用于临床研究和作为治疗效果的观察指标,近期日本学者还提出了“骨转化生化标志物应用于骨质疏松的指南2001”(后文简称“2001指南”)[1]。多数研究集中于这些指标在绝经后骨质疏松方面的应用,但在个体化临床应用方面还未明确阐明。
引用
收藏
页码:94 / 103
页数:10
相关论文
共 10 条
[1]   The characteristics of bone turnover in the second decade in relation to age and puberty development in healthy Japanese male and female subjects - Japanese Population-based Osteoporosis Study [J].
Matsukura, T ;
Kagamimori, S ;
Nishino, H ;
Yamagami, T ;
Iki, M ;
Kajita, E ;
Kagawa, Y ;
Yoneshima, H ;
Matsuzaki, T ;
Marumo, F .
ANNALS OF HUMAN BIOLOGY, 2003, 30 (01) :13-25
[2]   Monitoring individual response to hormone replacement therapy with bone markers [J].
Delmas, PD ;
Hardy, P ;
Garnero, P ;
Dain, MP .
BONE, 2000, 26 (06) :553-560
[3]   Serum CrossLaps for monitoring the response in individuals undergoing antiresorptive therapy [J].
Christgau, S ;
Bitsch-Jensen, O ;
Bjarnason, NH ;
Henriksen, EG ;
Qvist, P ;
Alexandersen, P ;
Henriksen, DB .
BONE, 2000, 26 (05) :505-511
[4]   A model to monitor the efficacy of alendronate treatment in women with osteoporosis using a biochemical marker of bone turnover [J].
Garnero, P ;
Darte, C ;
Delmas, PD .
BONE, 1999, 24 (06) :603-609
[5]   Biochemical markers of bone turnover reflect femoral bone loss in elderly women [J].
DresnerPollak, R ;
Parker, RA ;
Poku, M ;
Thompson, J ;
Seibel, MJ ;
Greenspan, SL .
CALCIFIED TISSUE INTERNATIONAL, 1996, 59 (05) :328-333
[6]  
Drug therapy for vertebral fractures in osteoporosis: Evidence that decreases in bone turnover and increases in bone mass both determine antifracture efficacy[J] . B.L. Riggs,L.J. Melton,W.M. O’Fallon.Bone . 1996 (3)
[7]  
Low bone mass and fast rate of bone loss at menopause: Equal risk factors for future fracture: A 15-year follow-up Study[J] . B.J. Riis,M.A. Hansen,A.M. Jensen,K. Overgaard,C. Christiansen.Bone . 1996 (1)
[8]   The effects of brisk walking on markers of bone and calcium metabolism in postmenopausal women [J].
Thorsen, K ;
Kristoffersson, A ;
Lorentzon, R .
CALCIFIED TISSUE INTERNATIONAL, 1996, 58 (04) :221-225
[9]  
Role Of Peak Bone Mass And Bone Loss In Postmenopausal Osteoporosis: 12 Year Study[J] . Marc A. Hansen,Kirsten Overgaard,Bente J. Riis,Claus Christiansen.BMJ: British Medical Journal . 1991 (6808)
[10]  
Biochemical markers of bone turnover and prediction of hip bone loss in older women: the study of os-teoporotic fractures. Bauer DC, Sklarin PM, Stone KL, et al. Journal of Bone and Mineral Research . 1999