重症急性胰腺炎对肠黏膜屏障损伤影响的研究进展

被引：18

作者：

单体栋 ^{[1
]}

吕韶燕 ^{[2
]}

张方信 ^{[1
]}

机构：

[1] 兰州军区兰州总医院消化内科

[2] 兰州大学第二医院内分泌科

来源：

胃肠病学 | 2010年 / 15卷 / 07期

关键词：

重症急性胰腺炎; 肠黏膜屏障; 损伤; 通透性; 免疫,黏膜;

D O I：

暂无

中图分类号：

R576 [胰腺疾病];

学科分类号：

100201 [内科学];

摘要：

肠黏膜屏障功能是肠道的重要特征之一,大量研究表明重症急性胰腺炎(SAP)患者易发生肠屏障功能障碍,而肠屏障功能障碍又可进一步继发感染,甚至诱发和加重全身炎症反应综合征(SIRS)、多器官功能障碍综合征(MODS)。本文就SAP对肠黏膜屏障损伤影响的研究进展作一简要综述。

引用

页码：439 / 441

页数：3

共 15 条

[1]

Evidence for tight junction protein disruption in intestinal mucosa of malignant obstructive jaundice patients [J].

Wang, Na ;

Yu, Huiling ;

Ma, Junji ;

Wu, Wenxin ;

Zhao, Dongqiang ;

Shi, Xiaodong ;

Tian, Hui ;

Jiang, Huiqing .

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 2010, 45 (02) :191-199

[2]

Intestinal Barrier Dysfunction in a Randomized Trial of a Specific Probiotic Composition in Acute Pancreatitis [J].

Besselink, Marc G. ;

van Santvoort, Hjalmar C. ;

Renooij, Willem ;

de Smet, Martin B. ;

Boermeester, Marja A. ;

Fischer, Kathelijn ;

Timmerman, Harro M. ;

Ali, Usama Ahmed ;

Cirkel, Geert A. ;

Bollen, Thomas L. ;

van Ramshorst, Bert ;

Schaapherder, Alexander F. ;

Witteman, Ben J. ;

Ploeg, Rutger J. ;

van Goor, Harry ;

van Laarhoven, Cornelis J. ;

Tan, Adriaan C. ;

Brink, Menno A. ;

van der Harst, Erwin ;

Wahab, Peter J. ;

van Eijck, Casper H. ;

Dejong, Cornelis H. ;

van Erpecum, Karel J. ;

Akkermans, Louis M. ;

Gooszen, Hein G. .

ANNALS OF SURGERY, 2009, 250 (05) :712-719

[3]

Role of tumor necrosis factor-α in acute pancreatitis:: From biological basis to clinical evidence [J].

Malleo, Giuseppe ;

Mazzon, Emanuela ;

Siriwardena, Ajith K. ;

Cuzzocrea, Salvatore .

SHOCK, 2007, 28 (02) :130-140

[4]

Breakdown of intestinal mucosa via accelerated apoptosis increases intestinal permeability in experimental severe acute pancreatitis [J].

Yasuda, Takeo ;

Takeyama, Yoshifumi ;

Ueda, Takashi ;

Shinzeki, Makoto ;

Sawa, Hidehiro ;

Nakajima, Takahiro ;

Kuroda, Yoshikazu .

JOURNAL OF SURGICAL RESEARCH, 2006, 135 (01) :18-26

[5]

Evaluation of intestinal mucosal permeability function in patients with acute pancreatitis [J].

Nagpal, Kamal ;

Minocha, Vivek Ratna ;

Agrawal, Vivek ;

Kapur, Suman .

AMERICAN JOURNAL OF SURGERY, 2006, 192 (01) :24-28

[6]

The role of p65 NF- k B/RelA in pancreatitis-induced kupffer cell apoptosis.[J].Yanhua Peng;Scott F. Gallagher;Regine Landmann;Krista Haines;Michel M. Murr.Journal of Gastrointestinal Surgery.2006, 6

[7]

Enterocyte apoptosis and barrier function are modulated by SIgA after exposure to bacteria and hypoxia/reoxygenation [J].

Diebel, LN ;

Liberati, DM ;

Dulchavsky, SA ;

Diglio, CA ;

Brown, WJ .

SURGERY, 2003, 134 (04) :574-580

[8]

Altered intestinal morphology and immunity in patients with acute necrotizing pancreatitis.[J].Basil J. Ammori;Alison Cairns;Michael F. Dixon;Michael Larvin;Michael J. McMahon.Journal of Hepato-Biliary-Pancreatic Surgery.2002, 4

[9]

Acute pancreatitis and bacterial translocation [J].

Cicalese, L ;

Sahai, A ;

Sileri, P ;

Rastellini, C ;

Subbotin, V ;

Ford, H ;

Lee, K .

DIGESTIVE DISEASES AND SCIENCES, 2001, 46 (05) :1127-1132

[10]

肠道微生态对三硝基苯磺酸诱导大鼠结肠炎肠黏膜上皮细胞紧密连接蛋白occludin保护作用的研究 [J].

张文远 ;

姜伟炜 .

临床消化病杂志, 2010, 22 (01) :21-24

← 1 2 →