二肽基肽酶4及其抑制剂的心血管效应

被引:6
作者
邓玉颖
张翼飞
王卫庆
宁光
机构
[1] 上海交通大学医学院附属瑞金医院内分泌代谢病科上海市内分泌代谢病临床医学中心
关键词
二肽基肽酶4; 二肽基肽酶4抑制剂; 糖尿病; 心血管效应;
D O I
暂无
中图分类号
R587.1 [糖尿病];
学科分类号
1002 ; 100201 ;
摘要
<正>糖尿病是威胁人类健康的全球性疾病,而糖尿病的大血管并发症是患者致残、致死的主要原因之一,65%的2型糖尿病患者死于心肌梗死和卒中。因此,研发一种具有心血管保护作用的糖尿病治疗药物迫在眉睫。二肽基肽酶4(DPP-4,又称腺苷酸脱氨酶结合蛋白、CD26)抑制剂作为一种新型口服降糖药,具有一定的心血管保护作用,且其部分作用通过抑制DPP-4对其心血管作用底物的裂解来实现。本文对DPP-4及其抑制剂的心血管效应作一综述。
引用
收藏
页码:635 / 639
页数:5
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