2型糖尿病与骨质疏松症相关性研究进展

被引：72

作者：

熊雪松

余显霞

机构：

[1] 湖北省鄂州市中心医院内分泌科

来源：

中国骨质疏松杂志 | 2017年 / 23卷 / 01期

关键词：

2型糖尿病; 骨质疏松; 骨折; 风险评估;

D O I：

暂无

中图分类号：

R580 []; R587.1 [糖尿病];

学科分类号：

100201 [内科学];

摘要：

流行病学调查发现,2型糖尿病(type 2 diabetes mellitus,T2DM)患者与健康人群相比其骨折事件的发生率明显增高,因此骨质疏松及其骨折需引起患者足够的重视。虽然不同研究显示T2DM患者骨密度(bone mineral density,BMD)变化有所不同,但其骨折风险始终增加。在分子机制研究层面,T2DM相关性骨质疏松的发生可能与胰岛素生长因子-1、硬骨素、葡萄糖毒性、降钙素、骨钙素、氧化应激等多种代谢因素改变有关,并且在动物和临床研究均发现治疗糖尿病和骨质疏松的药物使用可造成骨代谢改变。在T2DM骨质疏松的预防和治疗过程中,监测、诊断和预防骨质疏松的危险因素,控制血糖稳定,保证足够的钙和维生素D的摄入,预防跌倒以及加强锻练对降低骨折风险和改善生活质量有重要意义。

引用

页码：130 / 135

页数：6

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