抵抗素与冠心病

被引：11

作者：

胡龙江

吕湛

机构：

[1] 川北医学院附属医院心血管内科

来源：

国际病理科学与临床杂志 | 2010年 / 30卷 / 05期

关键词：

抵抗素; 冠心病; 动脉粥样硬化; 内皮细胞; 炎性反应;

D O I：

暂无

中图分类号：

R541.4 [冠状动脉（粥样）硬化性心脏病（冠心病）];

学科分类号：

100201 [内科学];

摘要：

人类抵抗素主要在单核细胞和巨噬细胞中表达,具有抵抗胰岛素的作用。然而,目前许多研究表明抵抗素与冠心病具有密切关系,一方面,急性心肌损伤通过斑块的破裂、炎性反应和应激等机制可刺激血浆抵抗素水平升高;另一方面,血浆抵抗素水平升高通过引起血管内皮细胞功能紊乱,诱导炎症反应和氧化应激,促进泡沫细胞的形成,促进血管平滑肌细胞增殖、迁移,促进血管内皮细胞增殖、迁移及毛细血管生成和促进冠状动脉钙化等机制导致冠心病。

引用

页码：437 / 440

页数：4

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